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. 2025 Aug 9.
doi: 10.1038/s41393-025-01112-x. Online ahead of print.

Increased risk of osteoarthritis in persons with spinal cord injury: a population-based longitudinal follow-up study in Taiwan

Chien-Po Liu  1 , Shin-Liang Pan  2   3
Affiliations

Increased risk of osteoarthritis in persons with spinal cord injury: a population-based longitudinal follow-up study in Taiwan

Chien-Po Liu et al. Spinal Cord. .

Abstract

Study design: Retrospective cohort study.

Objectives: To assess the relative risk of osteoarthritis (OA) in individuals with newly diagnosed spinal cord injury (SCI) compared to a matched non-SCI group.

Setting: Taiwan's Longitudinal Health Insurance Database.

Methods: We identified 1373 individuals aged 20-69 years with newly diagnosed SCI between 2002 and 2005 as the SCI group. A propensity-score-matched non-SCI group (N = 5492) with similar baseline demographic and clinical characteristics was selected for comparison. Both groups were followed until December 2011. OA-free survival was analyzed via Kaplan-Meier curves, and the association between SCI and OA risk was evaluated via stratified Cox proportional-hazards regression. To assess temporal risk variations, we performed landmark analysis with a 1-year cutoff, dividing follow-up into early (0-1 year) and long-term (≥1 year) periods.

Results: The respective incidence rates of OA for the SCI and non-SCI groups were 45.4 per 1000 person-years (95% confidence interval [CI], 40.1-50.1) and 31.6 per 1000 person-years (95% CI, 29.8-33.4). The hazard ratio of OA for the SCI group, as compared to the non-SCI group, was 1.52 (95% CI 1.34-1.72, p < 0.0001).

Conclusions: This population-based longitudinal follow-up study indicates that there is an increased long-term risk of OA in persons with SCI, underscoring the need for clinical vigilance and early diagnostic measures in this population. Further research is needed to explore the mechanisms underlying the association between these two conditions.

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Conflict of interest statement

Competing interests: The authors declare no competing interests. Ethical approval: This study was approved by the Research Ethics Committee of National Taiwan University Hospital. The approval number is 201912207RIND. All methods were performed in accordance with the relevant institutional and governmental guidelines and regulations. All individuals’ data were encrypted to protect individual privacy and allow for anonymous analysis. Therefore, it obviated the need for informed consent as the database consists of de-identified data intended for research use.

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References

    1. Baker-LePain JC, Lane NE. Role of bone architecture and anatomy in osteoarthritis. Bone. 2012;51:197–203. - PubMed - PMC
    1. Frontera JE, Mollett P. Aging with spinal cord injury: an update. Phys Med Rehabil Clin N Am. 2017;28:821–8. - PubMed
    1. Lal S. Premature degenerative shoulder changes in spinal cord injury patients. Spinal Cord. 1998;36:186–9. - PubMed
    1. Morgenroth DC, Gellhorn AC, Suri P. Osteoarthritis in the disabled population: a mechanical perspective. PM R. 2012;4:S20–7. - PubMed
    1. Wylie EJ, Chakera TM. Degenerative joint abnormalities in patients with paraplegia of duration greater than 20 years. Paraplegia. 1988;26:101–6. - PubMed

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