Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025;49(7):1135-1140.
doi: 10.32604/biocell.2025.062821. Epub 2025 Jul 25.

Eosinophils in Rheumatoid Arthritis: A Multifaceted Role in the Pathogenesis of the Disease

Alexander Blagov  1 , Michael Bukrinsky  2 , Aleksandra Utkina  3 , Gulalek Babayeva  4 , Vasily Sukhorukov  1 , Alexander Orekhov  5
Affiliations

Eosinophils in Rheumatoid Arthritis: A Multifaceted Role in the Pathogenesis of the Disease

Alexander Blagov et al. Biocell. 2025.

Abstract

Eosinophils are multifunctional granulocytes that contribute to the initiation and modulation of inflammation. Accumulating evidence suggests that eosinophils are adaptable leukocytes that orchestrate the resolution of inflammatory responses. The most prevalent chronic inflammatory illness, rheumatoid arthritis (RA), is typified by persistent synovitis that makes it hard for the disease to go away on its own. Interestingly, a unique subset of eosinophils known as regulatory eosinophils has been found in RA patients' synovium, especially while the disease is in remission. Pro-resolving signatures of regulatory eosinophils in the synovium are distinct from those of their lung counterparts. The most recent research on eosinophils and their function in this disease pathogenesis is compiled in this review. Based on the role of regulatory eosinophils, a new pathological model of inflammation resolution in RA is proposed, and potential therapeutic strategies aimed at enhancing the action of regulatory eosinophils in RA are proposed.

Keywords: Rheumatoid arthritis; cytokines; eosinophils; inflammation; lymphocytes; synovium.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The authors declare no conflicts of interest to report regarding the present study.

Figures

Figure 1:
Figure 1:
The general model of eosinophil participation in RA
See this image and copyright information in PMC

References

    1. Klareskog L, Rönnelid J, Saevarsdottir S, Padyukov L, Alfredsson L. The importance of differences; On environment and its interactions with genes and immunity in the causation of rheumatoid arthritis. J Intern Med. 2020;287(5):514–33. doi: 10.1111/joim.13058. - DOI - PubMed
    1. Li Y, Liu J, Hu Y, Cong C, Chen Y, Zhou Q. Crossroads: pathogenic role and therapeutic targets of neutrophil extracellular traps in rheumatoid arthritis. BIOCELL. 2024;48(1):9–19. doi: 10.32604/biocell.2023.045862. - DOI
    1. Sparks JA. Rheumatoid arthritis. Ann Intern Med. 2019;170(1):ITC1–16. doi: 10.7326/AITC201901010. - DOI - PubMed
    1. Bullock J, Rizvi SAA, Saleh AM, Ahmed SS, Do DP, Ansari RA, et al. Rheumatoid arthritis: a brief overview of the treatment. Med Princ Pract. 2018;27(6):501–7. doi: 10.1159/000493390. - DOI - PMC - PubMed
    1. Derksen VM, Huizinga TJ, van der Woude D. The role of autoantibodies in the pathophysiology of rheumatoid arthritis. Semin Immunopathol. 2017;39(4):437–46. doi: 10.1007/s00281-017-0627-z. - DOI - PMC - PubMed

LinkOut - more resources