Navigating the Landscape of Uterine Fibroid Treatment Using a Novel Scarless Technology (GYIDE): A Case Report

Abstract

Uterine fibroids (UFs) affect 70%-80% of women by age 50. Traditional treatments include medical management and invasive surgery. Recent advancements in fibroid treatment introduce less invasive methods like radiofrequency ablation (RFA), microwave ablation, uterine artery embolization, and MR-guided focused ultrasound. Accurate fibroid mapping and electrode placement are major challenges in the case of fibroid ablation. GYIDE, a scarless technology, demonstrates the feasibility for ultrasound-guided transcervical RFA. A 40-year-old woman with multiple intramural fibroids underwent RFA using GYIDE prior to hysterectomy. The procedure involved preoperative ultrasound, three-dimensional fibroid rendering, real-time mapping, and delivering the RFA for UF. Transcervical RFA targeted a 4 cm × 3.5 cm fibroid at 115 W for 5 min under ultrasound guidance. The GYIDE system enabled safe, precise RFA without complications. Intraoperative ultrasound confirmed effective ablation. Postthysterectomy analysis revealed no serosal perforation or thermal damage. The 4 mm navigation arm avoided cervical dilation, reducing discomfort. GYIDE delivers safe and precise transcervical RFA for UFs, with promising potential for expanded applications with advancing research.

Keywords: Case report; leiomyoma; minimally invasive surgical procedures; radiofrequency ablation; ultrasonography; uterine neoplasms.

Figure 1

Overview of the GYIDE system

Figure 2

Real-time two-dimensional ultrasonography images transferred to fibroid mapping reviewer application and annotations