Erosive oral lichen planus successfully treated with JAK3/TEC inhibitor ritlecitinib: A case report

doi:10.1016/j.jdcr.2025.05.017

Case Reports

. 2025 Jun 16:63:70-72.

doi: 10.1016/j.jdcr.2025.05.017. eCollection 2025 Sep.

Erosive oral lichen planus successfully treated with JAK3/TEC inhibitor ritlecitinib: A case report

Abigail Katz¹, Raphaella Lambert¹, Areeba Ahmed², Deep Patel¹, Gabriela Soto-Canetti¹, Jordan Talia¹, Jonas A Adalsteinsson^{3

4}

Affiliations

¹ Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York.
² Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
³ Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
⁴ Department of Dermatology, Landspitali University Hospital, Reykjavík, Iceland.

PMID: 40787044
PMCID: PMC12329467
DOI: 10.1016/j.jdcr.2025.05.017

Case Reports

Erosive oral lichen planus successfully treated with JAK3/TEC inhibitor ritlecitinib: A case report

Abigail Katz et al. JAAD Case Rep. 2025.

. 2025 Jun 16:63:70-72.

doi: 10.1016/j.jdcr.2025.05.017. eCollection 2025 Sep.

Authors

Abigail Katz¹, Raphaella Lambert¹, Areeba Ahmed², Deep Patel¹, Gabriela Soto-Canetti¹, Jordan Talia¹, Jonas A Adalsteinsson^{3

4}

Affiliations

¹ Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York.
² Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
³ Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
⁴ Department of Dermatology, Landspitali University Hospital, Reykjavík, Iceland.

PMID: 40787044
PMCID: PMC12329467
DOI: 10.1016/j.jdcr.2025.05.017

No abstract available

Keywords: Janus kinase 3 inhibition; bullous skin diseases; erosive oral lichen planus; ritlecitinib.

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Conflict of interest statement

None disclosed.

Figures

**Fig 1**
Baseline photo of the oral mucocutaneous lesions at the patient’s first visit at our practice.

**Fig 2**
Oral lesions after 4 weeks of treatment with ritlecitinib. Faint Wickham striae still present, confirming the diagnosis of OLP. *OLP*, oral lichen planus.

**Fig 3**
Oral mucocutaneous lesions significantly improved after 3 months of ritlecitinib.

See this image and copyright information in PMC

References

1. Ginat W., Mirowski, Culton D.A. UpToDate; 2023. Oral lichen planus: pathogenesis, clinical features, and diagnosis.https://www.uptodate.com/contents/oral-lichen-planus-pathogenesis-clinic...
1. Wu T., Bai Y., Jing Y., Chen F. What can we learn from treatments of oral lichen planus? Front Cell Infect Microbiol. 2024;14 doi: 10.3389/fcimb.2024.1279220. - DOI - PMC - PubMed
1. Cheng Y.S.L., Gould A., Kurago Z., Fantasia J., Muller S. Diagnosis of oral lichen planus: a position paper of the American Academy of Oral and Maxillofacial Pathology. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122(3):332–354. doi: 10.1016/j.oooo.2016.05.004. - DOI - PubMed
1. Korkitpoonpol N., Kanjanabuch P. Direct immunofluorescence cannot be used solely to differentiate among oral lichen planus, oral lichenoid lesion, and oral epithelial dysplasia. J Dent Sci. 2023;18(4):1669–1676. doi: 10.1016/j.jds.2023.01.025. - DOI - PMC - PubMed
1. Motamed-Sanaye A., Khazaee Y.F., Shokrgozar M., Alishahi M., Ahramiyanpour N., Amani M. JAK inhibitors in lichen planus: a review of pathogenesis and treatments. J Dermatolog Treat. 2022;33(8):3098–3103. doi: 10.1080/09546634.2022.2116926. - DOI - PubMed

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[1] Ginat W., Mirowski, Culton D.A. UpToDate; 2023. Oral lichen planus: pathogenesis, clinical features, and diagnosis.https://www.uptodate.com/contents/oral-lichen-planus-pathogenesis-clinic...

[2] Ginat W., Mirowski, Culton D.A. UpToDate; 2023. Oral lichen planus: pathogenesis, clinical features, and diagnosis.https://www.uptodate.com/contents/oral-lichen-planus-pathogenesis-clinic...

[3] Wu T., Bai Y., Jing Y., Chen F. What can we learn from treatments of oral lichen planus? Front Cell Infect Microbiol. 2024;14 doi: 10.3389/fcimb.2024.1279220. - DOI - PMC - PubMed

[4] Wu T., Bai Y., Jing Y., Chen F. What can we learn from treatments of oral lichen planus? Front Cell Infect Microbiol. 2024;14 doi: 10.3389/fcimb.2024.1279220. - DOI - PMC - PubMed

[5] Cheng Y.S.L., Gould A., Kurago Z., Fantasia J., Muller S. Diagnosis of oral lichen planus: a position paper of the American Academy of Oral and Maxillofacial Pathology. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122(3):332–354. doi: 10.1016/j.oooo.2016.05.004. - DOI - PubMed

[6] Cheng Y.S.L., Gould A., Kurago Z., Fantasia J., Muller S. Diagnosis of oral lichen planus: a position paper of the American Academy of Oral and Maxillofacial Pathology. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122(3):332–354. doi: 10.1016/j.oooo.2016.05.004. - DOI - PubMed

[7] Korkitpoonpol N., Kanjanabuch P. Direct immunofluorescence cannot be used solely to differentiate among oral lichen planus, oral lichenoid lesion, and oral epithelial dysplasia. J Dent Sci. 2023;18(4):1669–1676. doi: 10.1016/j.jds.2023.01.025. - DOI - PMC - PubMed

[8] Korkitpoonpol N., Kanjanabuch P. Direct immunofluorescence cannot be used solely to differentiate among oral lichen planus, oral lichenoid lesion, and oral epithelial dysplasia. J Dent Sci. 2023;18(4):1669–1676. doi: 10.1016/j.jds.2023.01.025. - DOI - PMC - PubMed

[9] Motamed-Sanaye A., Khazaee Y.F., Shokrgozar M., Alishahi M., Ahramiyanpour N., Amani M. JAK inhibitors in lichen planus: a review of pathogenesis and treatments. J Dermatolog Treat. 2022;33(8):3098–3103. doi: 10.1080/09546634.2022.2116926. - DOI - PubMed

[10] Motamed-Sanaye A., Khazaee Y.F., Shokrgozar M., Alishahi M., Ahramiyanpour N., Amani M. JAK inhibitors in lichen planus: a review of pathogenesis and treatments. J Dermatolog Treat. 2022;33(8):3098–3103. doi: 10.1080/09546634.2022.2116926. - DOI - PubMed

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Erosive oral lichen planus successfully treated with JAK3/TEC inhibitor ritlecitinib: A case report

Affiliations

Erosive oral lichen planus successfully treated with JAK3/TEC inhibitor ritlecitinib: A case report

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Affiliations

Conflict of interest statement

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