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. 2025 Aug 7;6(8):e70122.
doi: 10.1002/mco2.70122. eCollection 2025 Aug.

Meal-Induced NF-kB Activation in Mononuclear Cells Triggers Lumican Secretion and Promotes Chronic Kidney Disease in Metabolic Dysfunction-Associated Steatotic Liver Disease

Giovanni Musso  1 , Filippo Mariano  2 , Alberto Mella  2 , Silvia Pinach  2 , Roberto Gambino  2
Affiliations

Meal-Induced NF-kB Activation in Mononuclear Cells Triggers Lumican Secretion and Promotes Chronic Kidney Disease in Metabolic Dysfunction-Associated Steatotic Liver Disease

Giovanni Musso et al. MedComm (2020). .
No abstract available

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Conflict of interest statement

Giovanni Musso: no present or past financial or non‐financial competing interest to disclose. Filippo Mariano: no present or past financial or non‐financial competing interest to disclose. Mella Alberto: no present or past financial or non‐financial competing interest to disclose. Silvia Pinach: no present or past financial or non‐financial competing interest to disclose. Roberto Gambino: no present or past financial or non‐financial competing interest to disclose.

Figures

FIGURE 1
FIGURE 1
Meal tolerance test parameters. Data are presented as mean (SEM). (A) Correlation between postprandial NF‐kB activation in mononuclear cells (MNCs) and absolute values of eGFR and of AER in MASLD patients (cross‐sectional cohort, n = 85). (B) Plasma Monocyte Chemoattractant Protein (MCP)‐1 and Lumican during the standardized meal tolerance test. Patients (n = 52) were grouped according to the presence (n = 32) or absence (n = 20) of chronic kidney disease (CKD) at baseline. (C) Correlation between changes (%) in postprandial NF‐kB activation in MNCs and changes in absolute values of eGFR and of AER in MASH patients, grouped according to treatment arm (n = 52).
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References

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