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. 1985 Oct;74(10):1095-6.
doi: 10.1002/jps.2600741016.

Pulmonary elimination of 5-fluorouracil in anesthetized rats

Y H Kao, C Y Yang, R R Chen, J D Huang

Pulmonary elimination of 5-fluorouracil in anesthetized rats

Y H Kao et al. J Pharm Sci. 1985 Oct.

Abstract

The pharmacokinetics of 5-fluorouracil (5-FU) was investigated in tumor-free anesthetized rats. Blood samples in the carotid artery and in the right atrium were sampled by cannulation during the steady-state infusion of 5-FU. Serum and blood samples were assayed by HPLC. After comparing the steady-state concentration of 5-FU in the right carotid artery with that in the right atrium, it was concluded that there was no pulmonary elimination of 5-FU in the anesthetized rat.

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