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. 2025 Aug 8;13(8):e70784.
doi: 10.1002/ccr3.70784. eCollection 2025 Aug.

Right Ventricular Outflow Tract Mass in Antiphospholipid Syndrome

Mohammad Sahebjam  1 , Hamidreza Poorhosseini  2 , Arezoo Haji Ali  1 , Tayyebe Mohammad Gholizad  1 , Saba Mohammadzadeh  1
Affiliations

Right Ventricular Outflow Tract Mass in Antiphospholipid Syndrome

Mohammad Sahebjam et al. Clin Case Rep. .

Abstract

Antiphospholipid syndrome (APS) is well known for its association with arterial and venous thrombosis. Intracardiac thrombosis-more often involving the right atrium-is a serious manifestation of the disease. We describe an APS case with a thrombosis in the right ventricular outflow tract (RVOT), which underwent regression after aggressive anticoagulation.

Keywords: antiphospholipid syndrome; intra cardiac thrombosis; right ventricular outflow tract thrombosis; transthoracic echocardiography.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Transthoracic echocardiography in parasternal long axis, showing RVOT mass inserted close to pulmonary valve. RVOT, right ventricular outlet tract.
FIGURE 2
FIGURE 2
Transthoracic echocardiography in parasternal short axis, showing RVOT mass inserted close to pulmonary valve. RVOT, right ventricular outlet tract.
FIGURE 3
FIGURE 3
Computed tomography pulmonary angiogram showing a filling defect (15 × 10 mm) in RVOT suggestive of thrombosis (arrow). RVOT, right ventricular outlet tract.
FIGURE 4
FIGURE 4
Transthoracic echocardiography in parasternal short axis, showing RVOT mass regression (3 × 7 mm) (arrow). RVOT, right ventricular outlet tract.
FIGURE 5
FIGURE 5
Transthoracic echocardiography in parasternal long axis, showing RVOT mass regression (arrow). RVOT, right ventricular outlet tract.
See this image and copyright information in PMC

References

    1. Miyakis S., Lockshin M. D., Atsumi T., et al., “International Consensus Statement on an Update of the Classification Criteria for Definite Antiphospholipid Syndrome (APS),” Journal of Thrombosis and Haemostasis 4, no. 2 (2006): 295–306. - PubMed
    1. Barbhaiya M., Zuily S., Naden R., et al., “The 2023 ACR/EULAR Antiphospholipid Syndrome Classification Criteria,” Arthritis and Rheumatology 75, no. 10 (2023): 1687–1702. - PubMed
    1. Soltész P., Szekanecz Z., Kiss E., and Shoenfeld Y., “Cardiac Manifestations in Antiphospholipid Syndrome,” Autoimmunity Reviews 6, no. 6 (2007): 379–386. - PubMed
    1. Turiel M., Muzzupappa S., Gottardi B., Crema C., Sarzi‐Puttini P., and Rossi E., “Evaluation of Cardiac Abnormalities and Embolic Sources in Primary Antiphospholipid Syndrome by Transesophageal Echocardiography,” Lupus 9, no. 6 (2000): 406–412. - PubMed
    1. Erdogan D., Goren M. T., Diz‐Kucukkaya R., and Inanc M., “Assessment of Cardiac Structure and Left Atrial Appendage Functions in Primary Antiphospholipid Syndrome: A Transesophageal Echocardiographic Study,” Stroke 36, no. 3 (2005): 592–596. - PubMed

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