Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Jun 16;87(8):4975-4981.
doi: 10.1097/MS9.0000000000003442. eCollection 2025 Aug.

Exploring Cognitive Enhancers: from neurotherapeutics to ethical and regulatory challenges: a mini review

Affiliations
Review

Exploring Cognitive Enhancers: from neurotherapeutics to ethical and regulatory challenges: a mini review

Abdulbasit Opeyemi Muili et al. Ann Med Surg (Lond). .

Abstract

This manuscript provides an outlook on using cognitive enhancers and their ethical implications. Cognitive enhancers, including prescription medications like modafinil and methylphenidate, over-the-counter supplements such as ginseng and caffeine, and novel nootropic agents like gene therapy and stem cell interventions, improve cognitive functions such as memory, focus, and learning. While they have shown efficacy in treating neurodegenerative disorders like Alzheimer's disease and attention-deficit/hyperactivity disorder (ADHD), their growing use by healthy individuals raises ethical concerns. This paper addresses the benefits of cognitive enhancers, such as improved academic and professional performance, and the associated risks, including addiction, dependence, and long-term health consequences. It also delves into social and ethical issues, including disparities in access, fairness, coercion in competitive environments, and distinguishing between genuine and substance-enhanced achievements. Additionally, the paper examines current regulations and proposes stronger legal frameworks to address the increasing use of cognitive enhancers. In conclusion, while cognitive enhancers have potential therapeutic benefits, a balanced approach is needed to regulate their use and ensure they are not misused to gain unfair advantages, particularly in non-medical settings.

Keywords: cognitive; ethical; nootropic.

PubMed Disclaimer

Conflict of interest statement

Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. No conflict of interest declared.

Similar articles

  • Sexual Harassment and Prevention Training.
    Cedeno R, Bohlen J. Cedeno R, et al. 2024 Mar 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. 2024 Mar 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 36508513 Free Books & Documents.
  • Short-Term Memory Impairment.
    Cascella M, Al Khalili Y. Cascella M, et al. 2024 Jun 8. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. 2024 Jun 8. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 31424720 Free Books & Documents.
  • Management of urinary stones by experts in stone disease (ESD 2025).
    Papatsoris A, Geavlete B, Radavoi GD, Alameedee M, Almusafer M, Ather MH, Budia A, Cumpanas AA, Kiremi MC, Dellis A, Elhowairis M, Galán-Llopis JA, Geavlete P, Guimerà Garcia J, Isern B, Jinga V, Lopez JM, Mainez JA, Mitsogiannis I, Mora Christian J, Moussa M, Multescu R, Oguz Acar Y, Petkova K, Piñero A, Popov E, Ramos Cebrian M, Rascu S, Siener R, Sountoulides P, Stamatelou K, Syed J, Trinchieri A. Papatsoris A, et al. Arch Ital Urol Androl. 2025 Jun 30;97(2):14085. doi: 10.4081/aiua.2025.14085. Epub 2025 Jun 30. Arch Ital Urol Androl. 2025. PMID: 40583613 Review.
  • The Black Book of Psychotropic Dosing and Monitoring.
    DeBattista C, Schatzberg AF. DeBattista C, et al. Psychopharmacol Bull. 2024 Jul 8;54(3):8-59. Psychopharmacol Bull. 2024. PMID: 38993656 Free PMC article. Review.
  • The use of Open Dialogue in Trauma Informed Care services for mental health consumers and their family networks: A scoping review.
    Maude P, James R, Searby A. Maude P, et al. J Psychiatr Ment Health Nurs. 2024 Aug;31(4):681-698. doi: 10.1111/jpm.13023. Epub 2024 Jan 17. J Psychiatr Ment Health Nurs. 2024. PMID: 38230967

References

    1. Wood SC. The Enhancement and Impairment of Learning by Stimulants. UC San Diego Electronic Theses and Dissertations. San Diego: University of California; 2010. 1151.
    1. Schifano F, Catalani V, Sharif S, et al. Benefits and harms of ‘smart drugs’ (nootropics) in healthy individuals. Drugs 2022;82:633–47. - PubMed
    1. Napoletano F, Schifano F, Corkery JM, et al. The psychonauts’ world of cognitive enhancers. Front Psychiatry 2020;11:546796. - PMC - PubMed
    1. Pustovrh T. (Zlo)raba farmakoloških učinkovin za krepitev kognitivnih sposobnosti. In: Varnost in Zdravje Pri Delu. Ljubljana: Ministrstvo za delo, družino, socialne zadeve in enakemožnosti; 2015. http://www.osha.mddsz.gov.si/resources/files/Pustovrh-01Krepitev_kognici...
    1. Malanga G, Aguiar MB, Martinez HD, et al. New insights on dimethylaminoethanol (DMAE) features as a free radical scavenger. Drug Metab Lett 2012;6:54–59. - PubMed

LinkOut - more resources