Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Jun 25;87(8):5046-5055.
doi: 10.1097/MS9.0000000000003502. eCollection 2025 Aug.

Vitamin D and physical activity as co-modifiers of muscle health and function - a narrative exploration

Inshal Jawed  1 , Hafiza Quratul Ain  2 , Farah Abdul Razaq  3 , Muhammad Umair Qadir  1 , Shafaq Jabeen  4 , Farah Alam  5 , Maham Javaid  6 , Mehak Mobin  7 , Danaish Kumar  4 , Ruhul Rai  8 , Syed Ali Farhan Abbas  9 , Abu Huraira Bin Gulzar  10 , Agha Muhammad Wali Mirza  9 , Salma S Alrawa  11 , Wajeeha Imam  2
Affiliations
Review

Vitamin D and physical activity as co-modifiers of muscle health and function - a narrative exploration

Inshal Jawed et al. Ann Med Surg (Lond). .

Abstract

Bone health requires different factors to grow. One of the main requirements is vitamin D. Much of the regulation of calcium levels also affects muscle strength and function, protein synthesis, and other cellular activities. Furthermore, the benefits of vitamin D on the muscular system are comparable to those of physical activity in terms of shaping the structural and functional changes in muscles. Our paper focuses on the synergistic effects of physical exercise and vitamin D on metabolism how they can impact muscle health, including the physiological rationale, outcomes of its deficiency, and measures for counteraction thereto. Here, we outline the effect of combined interventions for optimizing muscle strength.

Keywords: bone; muscle strength; physical activity; vitamin D.

PubMed Disclaimer

Conflict of interest statement

Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. The authors declare that they do not have any conflict of interest.

Figures

Figure 1.
Figure 1.
Metabolism of vitamin D—flowchart.
Figure 2.
Figure 2.
Metabolism of vitamin D—graphical presentation.
Figure 3.
Figure 3.
Synergistic role of vitamin D and physical health on muscle health.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Girgis CM, Brennan-Speranza TC. Vitamin D and skeletal muscle: current concepts from preclinical studies. JBMR Plus 2021;5:e10575. - PMC - PubMed
    1. Holick MF. Vitamin D deficiency. N Engl J Med 2007;357:266–81. - PubMed
    1. Ceglia L. Vitamin D and its role in skeletal muscle. Curr Opin Clin Nutr Metab Care 2009;12:628–33. - PMC - PubMed
    1. Wolff AE, Jones AN, Hansen KE. Vitamin D and musculoskeletal health. Nat Clin Pract Rheumatol 2008;4:580–88. - PubMed
    1. Babraj JA, Vollaard NB, Keast C, et al. Extremely short duration high intensity interval training substantially improves insulin action in young healthy males. BMC Endocr Disord 2009;9:3. - PMC - PubMed

LinkOut - more resources