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Review
. 2025 Jun 25;87(8):5046-5055.
doi: 10.1097/MS9.0000000000003502. eCollection 2025 Aug.

Vitamin D and physical activity as co-modifiers of muscle health and function - a narrative exploration

Inshal Jawed  1 , Hafiza Quratul Ain  2 , Farah Abdul Razaq  3 , Muhammad Umair Qadir  1 , Shafaq Jabeen  4 , Farah Alam  5 , Maham Javaid  6 , Mehak Mobin  7 , Danaish Kumar  4 , Ruhul Rai  8 , Syed Ali Farhan Abbas  9 , Abu Huraira Bin Gulzar  10 , Agha Muhammad Wali Mirza  9 , Salma S Alrawa  11 , Wajeeha Imam  2
Affiliations
Review

Vitamin D and physical activity as co-modifiers of muscle health and function - a narrative exploration

Inshal Jawed et al. Ann Med Surg (Lond). .

Abstract

Bone health requires different factors to grow. One of the main requirements is vitamin D. Much of the regulation of calcium levels also affects muscle strength and function, protein synthesis, and other cellular activities. Furthermore, the benefits of vitamin D on the muscular system are comparable to those of physical activity in terms of shaping the structural and functional changes in muscles. Our paper focuses on the synergistic effects of physical exercise and vitamin D on metabolism how they can impact muscle health, including the physiological rationale, outcomes of its deficiency, and measures for counteraction thereto. Here, we outline the effect of combined interventions for optimizing muscle strength.

Keywords: bone; muscle strength; physical activity; vitamin D.

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Conflict of interest statement

Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. The authors declare that they do not have any conflict of interest.

Figures

Figure 1.
Figure 1.
Metabolism of vitamin D—flowchart.
Figure 2.
Figure 2.
Metabolism of vitamin D—graphical presentation.
Figure 3.
Figure 3.
Synergistic role of vitamin D and physical health on muscle health.
See this image and copyright information in PMC

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