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. 2025 Nov 1;82(11):1197-1199.
doi: 10.1001/jamaneurol.2025.2619.

Slowly Expanding Lesions in Pediatric-Onset Multiple Sclerosis

Valeria Pozzilli  1   2 , Ferran Prados Carrasco  1   3   4 , Neena Kim  1   5 , Omar Abdel-Mannan  1   5 , Riccardo Nistri  1   5 , Philipp Goebl  1   3 , Cheryl Hemingway  5 , Asthik Biswas  6 , Kshitij Mankad  6 , Sniya Sudhakar  6 , Amitav Parida  7 , Sukhvir Wright  7   8 , Evangeline Wassmer  7   8 , Michael Eyre  9   10 , Ming Lim  9   11 , Thomas Rossor  9   11 , Arman Eshaghi  1   3 , Frederik Barkhof  12   13 , Ermelinda De Meo  1 , Olga Ciccarelli  1   14 , Yael Hacohen  1   5
Affiliations

Slowly Expanding Lesions in Pediatric-Onset Multiple Sclerosis

Valeria Pozzilli et al. JAMA Neurol. .
No abstract available

Plain language summary

This cohort study examines the association between slowly expanding lesions and pediatric-onset multiple sclerosis among younger individuals, focusing on brain growth and disability progression.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Pozzilli reported receiving grants from European Charcot Foundation during the conduct of the study. Dr Hemingway reported receiving travel grants and consulting fees from UCB, travel grants and speaker honoraria from Roche, and honorarium and consulting fees from Novartis during the conduct of the study. Dr Wassmer reported receiving personal fees from Sciensus International B.V., SynaptixBio, and Immedica Pharma UK Lt advisory boards; speaker honorarium from Immedica Pharma UK Lt; and personal fees for meeting attendance from UCB outside the submitted work. Dr Lim reported receiving personal fees from Roche, Novartis, and Octapharma advisory boards and Octapharma study steering committee outside the submitted work. Dr Eshaghi reported receiving research grants from the Medical Research Council (MRC), National Institute for Health and Care Research, Innovate UK, Biogen, Merck, Roche, IXICO, and Icometrix; serving as an advisory board member of Merck Serono and Bristol Myers Squib (BMS); serving as founder and equity stake holder in Queen Square Analytics Limited; serving on the editorial board of Neurology (American Academy of Neurology); and receiving speaker honorarium from Roche and Neuraxapharm for educational sessions. Dr Barkhof reported receiving grants from Roche and Biogen PML educational website and personal fees from Merck steering committee outside the submitted work. Dr De Meo reported receiving other fees from BMS and speaker honoraria from Novartis outside the submitted work. Dr Ciccarelli reported receiving personal fees from Novartis (Data Safety Monitoring Board), Lundbeck, Merck, Biogen, and Neurology; nonfinancial support from ECTRIMS; and grants from NIHR, MRC, and UK MS Society outside the submitted work. No other disclosures were reported.

References

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    1. Calvi A, Tur C, Chard D, et al. Slowly expanding lesions relate to persisting black-holes and clinical outcomes in relapse-onset multiple sclerosis. Neuroimage Clin. 2022;35:103048. doi: 10.1016/j.nicl.2022.103048 - DOI - PMC - PubMed
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    1. Calvi A, Carrasco FP, Tur C, et al. ; MS SMART Investigators . Association of slowly expanding lesions on MRI with disability in people with secondary progressive multiple sclerosis. Neurology. 2022;98(17):e1783-e1793. doi: 10.1212/WNL.0000000000200144 - DOI - PubMed
    1. Preziosa P, Pagani E, Meani A, et al. Slowly expanding lesions predict 9-year multiple sclerosis disease progression. Neurol Neuroimmunol Neuroinflamm. 2022;9(2):e1139. doi: 10.1212/NXI.0000000000001139 - DOI - PMC - PubMed

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