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Editorial
. 2025 Jul 31;16(5):2495-2497.
doi: 10.14336/AD.2025.10731.

Mitochondrial Dysfunction in Aging and Age-related Disorders

Aida Adlimoghaddam  1   2   3
Affiliations
Editorial

Mitochondrial Dysfunction in Aging and Age-related Disorders

Aida Adlimoghaddam. Aging Dis. .

Abstract

Mitochondrial dysfunction is increasingly recognized as a unifying mechanism underlying aging and a wide range of age-related diseases. This special issue brings together recent advances that elucidate how impaired mitochondrial function contributes to neurodegenerative, cardiovascular, and metabolic disorders. The featured articles highlight molecular pathways of mitochondrial decline, its systemic consequences, and potential interventions aimed at restoring mitochondrial health. Collectively, these studies reinforce the concept that targeting mitochondrial integrity holds significant promise for promoting healthy aging and preventing chronic disease.

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References

    1. Adlimoghaddam A, Fayazbakhsh F, Mohammadi M, Babaei Z, Behrooz AB, Tabasi F, et al. (2025). Sex and region-specific disruption of autophagy and mitophagy in Alzheimer's disease: linking cellular dysfunction to cognitive decline. Cell Death Discov, 11:204. - PMC - PubMed
    1. Adlimoghaddam A, Snow WM, Stortz G, Perez C, Djordjevic J, Goertzen AL, et al. (2019). Regional hypometabolism in the 3xTg mouse model of Alzheimer's disease. Neurobiol Dis, 127:264-277. - PubMed
    1. Adlimoghaddam A, Odero GG, Glazner G, Turner RS, Albensi BC (2021). Nilotinib Improves Bioenergetic Profiling in Brain Astroglia in the 3xTg Mouse Model of Alzheimer's Disease. Aging Dis, 12:441-465. - PMC - PubMed
    1. Zhang H, Muhetarijiang M, Chen RJ, Hu X, Han J, Zheng L, et al. (2025). Mitochondrial Dysfunction: A Roadmap for Understanding and Tackling Cardiovascular Aging. Aging Dis, 16: 2575-2614. - PMC - PubMed
    1. Yuan R, Adlimoghaddam A, Zhu Y, Han X, Bartke A (2025). Early Life Interventions: Impact on Aging and Longevity. Aging Dis, 16: 2659-2673. - PMC - PubMed

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