18F-FDG PET/CT-based deep radiomic models for enhancing chemotherapy response prediction in breast cancer

Abstract

Enhancing the accuracy of tumor response predictions enables the development of tailored therapeutic strategies for patients with breast cancer. In this study, we developed deep radiomic models to enhance the prediction of chemotherapy response after the first treatment cycle. 18F-Fludeoxyglucose PET/CT imaging data and clinical record from 60 breast cancer patients were retrospectively obtained from the Cancer Imaging Archive. PET/CT scans were conducted at three distinct stages of treatment; prior to the initiation of chemotherapy (T1), following the first cycle of chemotherapy (T2), and after the full chemotherapy regimen (T3). The patient's primary gross tumor volume (GTV) was delineated on PET images using a 40% threshold of the maximum standardized uptake value (SUVmax). Radiomic features were extracted from the GTV based on the PET/CT images. In addition, a squeeze-and-excitation network (SENet) deep learning model was employed to generate additional features from the PET/CT images for combined analysis. A XGBoost machine learning model was developed and compared with the conventional machine learning algorithm [random forest (RF), logistic regression (LR) and support vector machine (SVM)]. The performance of each model was assessed using receiver operating characteristics area under the curve (ROC AUC) analysis, and prediction accuracy in a validation cohort. Model performance was evaluated through fivefold cross-validation on the entire cohort, with data splits stratified by treatment response categories to ensure balanced representation. The AUC values for the machine learning models using only radiomic features were 0.85(XGBoost), 0.76 (RF), 0.80 (LR), and 0.59 (SVM), with XGBoost showing the best performance. After incorporating additional deep learning-derived features from SENet, the AUC values increased to 0.92, 0.88, 0.90, and 0.61, respectively, demonstrating significant improvements in predictive accuracy. Predictions were based on pre-treatment (T1) and post-first-cycle (T2) imaging data, enabling early assessment of chemotherapy response after the initial treatment cycle. Integrating deep learning-derived features significantly enhanced the performance of predictive models for chemotherapy response in breast cancer patients. This study demonstrated the superior predictive capability of the XGBoost model, emphasizing its potential to optimize personalized therapeutic strategies by accurately identifying patients unlikely to respond to chemotherapy after the first treatment cycle.

Keywords: Breast cancer; Chemotherapy; PET/CT imaging; Radiomics model; Treatment response.

Fig. 1

The workflow of deep radiomics models

Fig. 2

Comparison of radiomics-only and combined model performance using ROC curves

Fig. 3

CT radiomics features correlation matrix

Fig. 4

PET T1 radiomics features correlation matrix

Fig. 5

PET T2 radiomics features correlation matrix

Fig. 6

Decision curve analysis (XGBoost vs. logistic regression vs. random forest)