The China Alzheimer Report 2025

Abstract

With the sustained growth of the economy and significant changes in social demographics, the issue of elderly-related diseases has increasingly drawn attention, particularly. Alzheimer's disease (AD), as a representative disease of neurodegenerative diseases, has become a major challenge, affecting the health and quality of life of the elderly population severely. In recent years, the incidence, prevalence and mortality rates of AD have increased in China, imposing substantial economic burdens on families, society and the entire healthcare system. To proactively address this challenge and respond to the national 'Healthy China Action' initiative, leading experts from authoritative institutions jointly authored the China Alzheimer Report 2025. Building on previous editions, this report updates epidemiological data on AD in China, thoroughly analyses the latest economic burdens of the disease and comprehensively evaluates the current status of AD diagnosis and treatment services, as well as the allocation of public health resources in our country. Its release reflects China's progress in AD research and prevention, underscores societal concern for elderly health and aims to provide scientific guidance and data support for AD prevention, diagnosis and treatment. It also facilitates academic exchanges and cooperation, enhancing public awareness and promoting active participation in elderly healthcare, towards achieving 'healthy ageing' in China.

Keywords: Cognition Disorders.

Figure 1. Flowchart of the report search process. CNKI, China National Knowledge Infrastructure.

Figure 2. Newly registered therapy trials for Alzheimer’s disease. (1) Secondary indication: Left to right: Flos gossypii flavonoids tablet, anti-depression drug, rosiglitazone, canagliflozin, canagliflozin, lacosamide and levetiracetam, cholestyramine, piperazine ferulate tablets; (2) AD pathology: Left to right: CNP520, GV-971, lecanemab, gantenerumab, 50561, SHR1707, donanemab, SHR1707, GV-971, GV-971, citicoline, donepezil+GV-971, protein polymer alitol (ALEETO), remternetug, CM383, donepezil dihydroxynaphthalate; (3) Neuromodulation: Left to right: Theta burst TMS, rTMS, light therapy, light therapy, tACS, tACS+40 Hz sound, 4 Hz tACS, VNS, TMS, HD-tDCS, tDCS+cognitive training, rTMS, tES, TUS, photobiomodulation, photobiomodulation, 10 Hz rTMS, taVNS, taVNS, TMS, TMS, TMS, TMS, TMS, TMS, tACS; (4) Traditional Chinese medicine: Left to right: Kangshuailao Pian, acupuncture, Smart soup, EAS, Astragalus, Astragalus, yangxieqingnao Pian, Weilibai Capsule, acupuncture, Shenggonghuanglianjiedu Fang, Huanshao Dan+acupuncture, Tai chi+Huanshao Dan, EAS, acupuncture+cognitive training, Polygonum cuspidatum Yizhi granules, Bushen Huazhuo formula, Regulating Heart and Kidney, electroacupuncture+TMS, nourishing blood oral liquid, Shenghui Yizhi Tang, Wujia Yizhi granules, Electroacupuncture, Astragalus Membranaceus Root, acupuncture; (5) Cell therapy: Left to right: Allogenic adipose MSC Exos, mast cell activation, recombinant human serum albumin, regulatory T cells injection, stem cell-derived small extracellular vesicles; (6) Other: Left to right: ant-osteoporosis, cognitive training+aerobic exercise, faecal microbial transplant, probiotics, lifestyle, dental health management, periodontal therapy, cognitive training, nutrition+exercise+cognitive training, Yeast β-glucan, cognitive training, music therapy, tRNS, faecal microbial transplant, Probio-M8, remote ischaemic conditioning, music therapy, olfactory training, ketogenic diet, experimental sleep deprivation; (7) Surgery: Left to right: deep cervical lymphatic vessel vein anastomosis and lymphatic trunk decompression, deep cervical lymphaticovenous anastomosis, cervical lymphatic vein bypass surgery, cervical deep lymphatic vein anastomosis, deep cervical lymphaticovenous anastomosis, deep cervical lymphaticovenous anastomosis surgery, deep cervical lymphovenous bypass, lymphaticovenous anastomosis. AD, Alzheimer’s disease; EAS, electrical acupoint stimulation; Exos, exosomes; HD, high definition; MSC, mesenchymal stem cell; rTMS, repetitive TMS; tACS, transcranial alternating current stimulation; taVNS, transcutaneous auricular VNS; tDCS, transcranial direct current stimulation; tES, transcranial electrical stimulation; TMS, transcranial magnetic stimulation; tRNS, transcranial random noise stimulation; TUS, transcranial ultrasound stimulation; VNS, vagus nerve stimulation.