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Case Reports
. 2025;85(4):857-860.

Penile calciphylaxis

Ornela D Piñero  1 , Patricia A Fernández Pardal  2 , Mauro Coringrato  2 , Lucila Marchetta  2 , Lara Marotte  2 , Viviana Leiro  2
Affiliations
  • PMID: 40793897
Free article
Case Reports

Penile calciphylaxis

Ornela D Piñero et al. Medicina (B Aires). 2025.
Free article

Abstract
in English, Spanish

Calciphylaxis is a rare, highly mortal disease, typically diagnosed in patients with end-stage renal disease. This disorder usually presents as necrotic ulcers in acral or adipose areas. Penile necrosis due to calciphylaxis is an uncommon condition with a poor prognosis. Few cases have been described in the literature. We present the case of a 45-year-old male with a history of type 2 diabetes and chronic renal failure on dialysis, who developed painful necrotic ulcers on the glans, had altered phosphocalcic metabolism, and was found to have calcium deposits on imaging studies. Treatment with intravenous sodium thiosulfate was initiated, resulting in favorable evolution.

La calcifilaxis es una enfermedad rara, de elevada mortalidad, diagnosticada generalmente en pacientes con enfermedad renal terminal. Este trastorno se presenta típicamente como úlceras necróticas en áreas acrales o adiposas. La necrosis de pene secundaria a calcifilaxis es una entidad poco frecuente que conlleva mal pronóstico. Existen pocos reportes en la literatura. Se presenta el caso de un varón de 45 años con antecedentes de diabetes tipo 2 e insuficiencia renal crónica en diálisis, que desarrolló úlceras necróticas dolorosas en glande, presentaba alteración del metabolismo fosfocálcico y se constató en estudios de imágenes depósito de calcio. Se inició tratamiento con tiosulfato de sodio endovenoso, con evolución favorable.

Keywords: calcific arteriolopathy; calciphylaxis; chronic kidney disease; penile ulcer.

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