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Case Reports
. 2025 Aug;53(8):3000605251364059.
doi: 10.1177/03000605251364059. Epub 2025 Aug 12.

A case report of retroperitoneal leiomyosarcoma originating from the right ovarian vein and invading the right renal vein and inferior vena cava

Chengbin Lu  1 , Leyu Zhang  1 , Benmo Xu  1 , Tianyu Li  1 , Die Fan  1 , Changyang Li  1 , Yuanlong Shi  1 , Xin Li  1 , Bin Zhao  1
Affiliations
Case Reports

A case report of retroperitoneal leiomyosarcoma originating from the right ovarian vein and invading the right renal vein and inferior vena cava

Chengbin Lu et al. J Int Med Res. 2025 Aug.

Abstract

A woman in her early 50s was admitted to our hospital with a right retroperitoneal tumor that had been detected >1 year ago. Imaging studies revealed a mass in the right middle and lower retroperitoneum, which involved the upper portion of the right fallopian tube and caused dilated hydronephrosis of the right renal pelvis and calyces. Initial diagnosis suggested benign intraventricular smooth muscle neoplasia. She underwent surgical resection of the right retroperitoneal tumor, along with thrombectomy of the right renal vein and inferior vena cava, as well as artificial revascularization of the right renal vein. Postoperative pathology confirmed retroperitoneal smooth muscle sarcoma. She received postoperative chemotherapy with ifosfamide and doxorubicin as well as anticoagulation therapy with rivaroxaban. One year later, follow-up imaging revealed multiple nodules in the right middle and lower abdomen, a blurred nodule in the tail of the pancreas, and a dilated pancreatic duct in the distal pancreas, raising suspicion of metastasis.

Keywords: Retroperitoneal sarcoma; case report; inferior vena cava; ovarian vein; renal vein; smooth muscle sarcoma.

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Conflict of interest statement

Declaration of conflicting interestThe authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1.
Figure 1.
Preoperative enhanced CT of the abdomen. CT: computed tomography.
Figure 2.
Figure 2.
Preoperative enhanced MRI of the abdomen. MRI: magnetic resonance imaging.
Figure 3.
Figure 3.
Intraoperative specimens.
Figure 4.
Figure 4.
HE staining results on postoperative pathology. HE: hematoxylin and eosin.
Figure 5.
Figure 5.
Immunohistochemical findings on postoperative pathology.
See this image and copyright information in PMC

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