High-sensitivity point-of-care measurement of cardiac troponin

Louise Cullen¹, Johannes Mair², Ola Hammarsten³, Carsten Stengaard⁴, Jasper Boeddinghaus⁵, Lori B Daniels⁶, Kurt Huber⁷, Evangelos Giannitsis⁸, Allan S Jaffe⁹, Dorien M Kimenai¹⁰, Konstantin A Krychtiuk¹¹, Bertil Lindahl¹², Martin Möckel¹³, Christian Mueller⁵, Matthias Thielmann¹⁴, Kristian Thygesen⁴, Nicholas L Mills^{10

15}

Affiliations

¹ Emergency and Trauma Centre, Royal Brisbane and Women's Hospital, Butterfield St, Herston, Brisbane, Queensland 4029, Australia.
² Department of Internal Medicine III-Cardiology and Angiology, Innsbruck Medical University, Christoph-Probst-Platz 1, Innrain 52 A, Fritz-Pregl-Straße 3, 6020 Innsbruck, Austria.
³ Department of Clinical Chemistry and Transfusion Medicine, University of Gothenburg, Universitetsplatsen 1, 405 30 Gothenburg, Sweden.
⁴ Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Blvd. 99, 8200 Aarhus, Denmark.
⁵ Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Spitalstrasse 2, CH-4031, Switzerland.
⁶ Department of Medicine, Sulpizio Cardiovascular Center, University of California, San Diego, 9434 Medical Center Dr, La Jolla, CA 92037, USA.
⁷ Faculty of Medicine, Sigmund Freud University, Campus Prater, Freudplatz 1+3, A-1020 Vienna, Austria.
⁸ Department of Cardiology, University Hospital Heidelberg, Im Neuenheimer Feld 672, 69120, Germany.
⁹ Departments of Cardiology and Laboratory Medicine and Pathology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA.
¹⁰ BHF Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.
¹¹ Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria.
¹² Department of Medical Sciences, University of Uppsala, Akademiska Sjukhuset Ing 40, SE-751 85 Uppsala, Sweden.
¹³ Division of Emergency and Acute Medicine, Charité-Universitätsmedizin, Charitéplatz 1, 10117 Berlin, Germany.
¹⁴ Department of Thoracic and Cardiovascular Surgery, West-German Heart and Vascular Center, University of Duisburg-Essen, Hufelandstraße 55, 45122 Essen, Germany.
¹⁵ Usher Institute, University of Edinburgh, 5 Little France Rd, Edinburgh EH16 4UX, UK.

PMID: 40795130
DOI: 10.1093/eurheartj/ehaf407

High-sensitivity point-of-care measurement of cardiac troponin

Louise Cullen et al. Eur Heart J. 2025.

. 2025 Aug 7:ehaf407.

doi: 10.1093/eurheartj/ehaf407. Online ahead of print.

Authors

Affiliations

¹ Emergency and Trauma Centre, Royal Brisbane and Women's Hospital, Butterfield St, Herston, Brisbane, Queensland 4029, Australia.
² Department of Internal Medicine III-Cardiology and Angiology, Innsbruck Medical University, Christoph-Probst-Platz 1, Innrain 52 A, Fritz-Pregl-Straße 3, 6020 Innsbruck, Austria.
³ Department of Clinical Chemistry and Transfusion Medicine, University of Gothenburg, Universitetsplatsen 1, 405 30 Gothenburg, Sweden.
⁴ Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Blvd. 99, 8200 Aarhus, Denmark.
⁵ Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Spitalstrasse 2, CH-4031, Switzerland.
⁶ Department of Medicine, Sulpizio Cardiovascular Center, University of California, San Diego, 9434 Medical Center Dr, La Jolla, CA 92037, USA.
⁷ Faculty of Medicine, Sigmund Freud University, Campus Prater, Freudplatz 1+3, A-1020 Vienna, Austria.
⁸ Department of Cardiology, University Hospital Heidelberg, Im Neuenheimer Feld 672, 69120, Germany.
⁹ Departments of Cardiology and Laboratory Medicine and Pathology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA.
¹⁰ BHF Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.
¹¹ Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria.
¹² Department of Medical Sciences, University of Uppsala, Akademiska Sjukhuset Ing 40, SE-751 85 Uppsala, Sweden.
¹³ Division of Emergency and Acute Medicine, Charité-Universitätsmedizin, Charitéplatz 1, 10117 Berlin, Germany.
¹⁴ Department of Thoracic and Cardiovascular Surgery, West-German Heart and Vascular Center, University of Duisburg-Essen, Hufelandstraße 55, 45122 Essen, Germany.
¹⁵ Usher Institute, University of Edinburgh, 5 Little France Rd, Edinburgh EH16 4UX, UK.

PMID: 40795130
DOI: 10.1093/eurheartj/ehaf407

Abstract

New technologies enabling access to high-sensitivity cardiac troponin (hs-cTn) assays at the point of care (POC) are available for routine use. POC technology can accelerate cardiac troponin testing within the hospital setting and support testing in other healthcare environments. Pre-analytical and analytical issues unique to POC testing are discussed. The opportunities and the evidence needed to support the routine use of hs-cTn POC assays in clinical care are outlined. Based on recent developments, the potential impact of hs-cTn at the POC in multiple clinical settings is described, and a roadmap of the steps required for successful implementation is provided.

Keywords: Cardiac troponin; High-sensitivity; Myocardial infarction; Point of care.

© The Author(s) 2025. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.

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High-sensitivity point-of-care measurement of cardiac troponin

Affiliations

High-sensitivity point-of-care measurement of cardiac troponin

Authors

Affiliations

Abstract

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