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Review
. 2025 Aug 13;42(5):48.
doi: 10.1007/s10585-025-10364-z.

MicroRNAs in the abscopal effect: bridging radiotherapy and systemic anti-tumor immunity for enhanced cancer therapy

Fatemeh Hosseinpour-Soleimani  1   2 , Amir Tajbakhsh  3   4 , Zahra Salmasi  5   6 , Mohammad-Taha Pirsalehi  7 , Cambyz Irajie  8
Affiliations
Review

MicroRNAs in the abscopal effect: bridging radiotherapy and systemic anti-tumor immunity for enhanced cancer therapy

Fatemeh Hosseinpour-Soleimani et al. Clin Exp Metastasis. .

Abstract

The abscopal effect (AE) in oncology, where localized radiation therapy (RT) triggers a systemic anti-tumor immune response, holds great promise for revolutionizing cancer treatment. Emerging evidence suggests microRNAs (miRNAs), small non-coding RNAs, are essential in mediating the intricate interactions among the tumor, immune system, and tumor microenvironment underlying the AE. miRNAs, both within the tumor and circulating as exosomal cargo, can regulate gene expression to modulate the tumor microenvironment, enhance antigen presentation, and activate anti-tumor immunity. This miRNA-mediated intercellular communication can influence the radiation response, including tumor radiosensitivity, DNA damage repair, and apoptosis. Targeting specific miRNAs or leveraging miRNA-based therapies may sensitize tumors to radiation-induced immune responses, leading to more robust and durable AEs. Understanding the epigenetic regulation of the AE by miRNAs offers novel strategies to harness this phenomenon for improved cancer outcomes. Exploring the intersection of miRNAs, radiation, and the immune system holds the promise of developing more effective, personalized radiotherapy approaches that can unleash the body's defenses against metastatic disease. Unlocking the power of miRNA-mediated signaling may be the important key to unlocking the full potential of AE in the field of cancer treatment.

Keywords: Abscopal effect; Adverse reactions; Chemoradiotherapy; Epigenetic variations; Immunoradiotherapy; Local vaccine; Radiotherapy; Systemic anti-tumor immunity.

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Conflict of interest statement

Declarations. Conflict of interest: The authors declare no competing interests. Ethical approval: Ethical approval was not required for this review article, as it does not involve any human or animal subjects.

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