Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Aug 12;25(1):840.
doi: 10.1186/s12884-025-07993-3.

Nomogram of the anterior cerebral artery doppler indices at 11-13+6 weeks of gestation

Ornnat Wanasitchaiwat  1 , Supitchaya Surasereewong  1 , Orawan Supapueng  2 , Tachjaree Panchalee  1 , Sakita Moungmaithong  3
Affiliations

Nomogram of the anterior cerebral artery doppler indices at 11-13+6 weeks of gestation

Ornnat Wanasitchaiwat et al. BMC Pregnancy Childbirth. .

Abstract

Objective: To establish nomograms of anterior cerebral artery (ACA) Doppler indices during 11-13+6 weeks of gestation.

Methods: A descriptive cross-sectional study was conducted on low-risk singleton pregnancies with healthy fetuses. The ACA Doppler spectral waveforms were obtained using transabdominal Doppler sonography, in the same plane as the nuchal translucency measurement. The normative data were analyzed and constructed for the 5th, 10th, 50th, 90th, and 95th percentiles of ACA Doppler indices during 11-13+6 weeks of gestation.

Results: A total of 216 low-risk singleton pregnancies with healthy fetuses were enrolled in this study; 12 pregnancies were excluded due to duplicating data, affected fetuses by Thalassemia disease, abortion, fetal structural anomalies, fetal growth abnormalities, or uninformed or unrevealed underlying medical conditions. Anterior cerebral artery Doppler was measured, and the nomograms for ACA Doppler indices (ACA-PI, ACA-RI, and ACA-PSV), including the 5th, 10th, 50th, 90th, and 95th percentiles during the gestational period of 11-13+6 weeks, were established. The range of 5th - 95th percentile of ACA-PI, ACA-RI and ACA-PSV during 11 weeks of gestation were 1.15-1.86, 0.65-0.82 and 6.76-14.40, respectively, during 12 weeks of gestation were 1.22-1.90, 0.65-0.88 and 7.09-15.03, respectively and during 13 weeks of gestation were 1.26-1.82, 0.67-0.84 and 7.69-17.40, respectively.

Conclusion: During 11-13+6 weeks of gestation, the ACA-PI and ACA-RI values remained relatively constant, while PSV values gradually increased with gestation.

Keywords: Anterior cerebral artery; Doppler; First-trimester; Nomogram; Screening.

PubMed Disclaimer

Conflict of interest statement

Declarations. Ethics approval and consent to participate: The research protocol was approved by the institutional review board of Siriraj Hospital (COA no. Si181/2023). Consent for publication: All participants provided written informed consent to participate in the study and for the publication of anonymized data resulting from the research. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
A Color Doppler mapping of internal carotid artery, anterior cerebral artery and pericallosal artery in midsagittal plane. B Pulsed-wave Doppler aquisition of anterior cerebral artery
Fig. 2
Fig. 2
Plots of anterior cerebral artery pulsatility index (ACA-PI) with reference values at the 5th, 50th, and 95th percentiles during 11-13+6 weeks of gestation
Fig. 3
Fig. 3
Plots of anterior cerebral artery resistance index (ACA-RI) with reference values at the 5th, 50th, and 95th percentiles during 11-13+6 weeks of gestation
Fig. 4
Fig. 4
Plots of anterior cerebral artery peak systolic velocity index (ACA-PSV) with reference values at the 5th, 50th, and 95th percentiles during 11-13+6 weeks of gestation
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Nagaraj UD, Kline-Fath BM. Clinical applications of fetal MRI in the brain. Diagnostics. 2022. 10.3390/diagnostics12030764. - PMC - PubMed
    1. Tahir RA, et al. Anterior cerebral artery variant anatomy and pathology. J Vasc Interv Neurol. 2019;19. https://pubmed.ncbi.nlm.nih.gov/31308866/. - PMC - PubMed
    1. Klostranec JM, Krings T. Cerebral neurovascular embryology, anatomic variations, and congenital brain arteriovenous lesions. J NeuroIntervent Surgury. 2021. 10.1136/neurintsurg-2021-018607. - PubMed
    1. Engels AC, et al. Sonographic detection of central nervous system defects in the first trimester of pregnancy. Prenat Diagn. 2016;36:266–73. - PubMed
    1. Degani S. Evaluation of Fetal cerebrovascular Circulation and Brain Development The Role of Ultrasound and Doppler, vol. 33. Elsevier Inc; 2009. p. 259–69. - PubMed

LinkOut - more resources