Lorlatinib in ALK-positive non-small cell lung cancer: final survival data that reshape the therapeutic landscape
- PMID: 40799415
- PMCID: PMC12337068
- DOI: 10.21037/tlcr-2025-466
Lorlatinib in ALK-positive non-small cell lung cancer: final survival data that reshape the therapeutic landscape
Keywords: Anaplastic lymphoma kinase-positive non-small cell lung cancer (ALK-positive NSCLC); central nervous system metastases (CNS metastases); long-term survival; lorlatinib; tyrosine kinase inhibitors (TKIs).
Conflict of interest statement
Conflicts of Interest: The author has completed the ICMJE uniform disclosure form (available at https://tlcr.amegroups.com/article/view/10.21037/tlcr-2025-466/coif). Y.K. has received research grant support from the Japan Lung Cancer Society, SGH Foundation, and the Japan Research Foundation for Clinical Pharmacology. These grants were administered through the author’s affiliated institution and are unrelated to the submitted work. The author has no other conflicts of interest to declare.
Comment on
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Final Overall Survival and Long-Term Safety of Lorlatinib in Patients With ALK-Positive NSCLC From the Pivotal Phase 2 Study: A Brief Report.J Thorac Oncol. 2025 Apr;20(4):513-520. doi: 10.1016/j.jtho.2024.11.021. Epub 2024 Nov 22. J Thorac Oncol. 2025. PMID: 39581380 Clinical Trial.
References
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- Solomon BJ, Bauer TM, Mok TSK, et al. Efficacy and safety of first-line lorlatinib versus crizotinib in patients with advanced, ALK-positive non-small-cell lung cancer: updated analysis of data from the phase 3, randomised, open-label CROWN study. Lancet Respir Med 2023;11:354-66. 10.1016/S2213-2600(22)00437-4 - DOI - PubMed
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