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. 2025 Aug 11:13:goaf076.
doi: 10.1093/gastro/goaf076. eCollection 2025.

Pancreatic cancer mortality trend in Montenegro, 1990-2018

Mirjana Nedović Vuković  1   2 , Marina Jakšić  2   3 , Brigita Smolović  2   4 , Miloš Lukić  4 , Adrijana Vujović  5
Affiliations

Pancreatic cancer mortality trend in Montenegro, 1990-2018

Mirjana Nedović Vuković et al. Gastroenterol Rep (Oxf). .

Abstract

Background: According to the Global Cancer Observatory 2020 report, pancreatic cancer occupies the 11th position among the leading causes of cancer-related mortality in both sexes, with nearly 500,000 deaths annually worldwide. This study aimed to evaluate the trend of mortality due to pancreatic cancer in Montenegro from 1990 to 2018 and to contribute to the effective planning of preventive strategies for pancreatic cancer as well as future health policies and initiatives.

Methods: We utilized national data on the causes of death from pancreatic cancer and codes 157 from the 9th and C25 from the 10th revision of the International Classification of Diseases. The trend was described by using Joinpoint, Poisson, and linear regression.

Results: Mortality rates of pancreatic cancer in Montenegro consistently increased (P < 0.05) for the overall level for both men and women, with the average annual percentage change (AAPC) in the AAPC order (95% confidence interval): 1.7% (0.9%-2.5%) overall, 1.3% (0.4%-2.1%) in men, and 2.2% (0.9%-3.5%) in women. The majority of those who died from pancreatic cancer were aged 65-74 years (32.7%), 55-64 years (26.3%), and 75-84 years (24.1%).

Conclusions: The persistent increase in pancreatic cancer mortality rates in Montenegro, observed in both men and women, highlights a concerning public health trend. With the highest proportion of deaths occurring among individuals aged 55-84 years, these findings underscore the urgent need for policymakers to implement a national strategy targeting early detection, prevention, and improved management, especially among the most affected age groups.

Keywords: Montenegro; mortality; pancreatic cancer; trend.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could influence the work reported in this study.

Figures

Figure 1.
Figure 1.
Joinpoint regression analysis of pancreatic cancer mortality rates in Montenegro from 1990 to 2018. *APC was significantly different from zero, P < 0.05.
Figure 2.
Figure 2.
Distribution of pancreatic cancer mortality by age groups in Montenegro, 1990–2018. The y-axis represents percentage and x-axis represents age groups.
See this image and copyright information in PMC

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