Charting the path in rodent functional neuroimaging

Alessandro Gozzi¹, Alexia Stuefer¹, Filomena Grazia Alvino¹, Valeria Bedin^{1

2}, Christopher Cover³, Chaewon Kang¹, Alberto Galbusera¹, Rita Gil⁴, Silvia Gini^{1

2}, Elizabeth de Guzman¹, Gabriel Desrosiers-Grégoire^{5

6}, Daniel Gutierrez-Barragan¹, Francesca Mandino⁷, Jean-Charles Mariani¹, Edoardo Micotti⁸, Henning Reimann⁹, Marco Pagani^{1

10

11}, Chiara Pepe^{1

2}, David Sastre-Yagüe¹, Mila Urosevic^{1

5}, Mafalda Valente⁴, Roberta Vertullo^{1

2}, Rossella Canese¹², Anna Devor¹³, Joanes Grandjean^{14

15}, Itamar Kahn¹⁶, Shella D Keiholz¹⁷, Evelyn M R Lake^{17

18}, Nan Li¹⁹, Noam Shemesh⁴, Yen-Yu Ian Shih^{20

21

22

23}, Valerio Zerbi^{24

25}, Nanyin Zhang^{26

27}

Affiliations

¹ Functional Neuroimaging Laboratory, Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, Rovereto, Italy.
² Center for Mind and Brain Sciences, University of Trento, Rovereto, Italy.
³ Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States.
⁴ Champalimaud Research, Champalimaud Foundation, Lisbon, Portugal.
⁵ Computational Brain Anatomy Laboratory, Cerebral Imaging Center, Douglas Mental Health University Institute, Montreal, Canada.
⁶ Integrated Program in Neuroscience, McGill University, Montreal, Canada.
⁷ Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States.
⁸ Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy.
⁹ Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrück Center for Molecular Medicine, Helmholtz Association of German Research Centers (HZ), Berlin, Germany.
¹⁰ Autism Center, Child Mind Institute, New York, NY, United States.
¹¹ IMT School for Advanced Studies, Lucca, Italy.
¹² Istituto Superiore di Sanità, Rome, Italy.
¹³ Department of Biomedical Engineering, Boston University, Boston, MA, United States.
¹⁴ Donders Institute for Brain, Behaviour, and Cognition, Radboud University, Nijmegen, The Netherlands.
¹⁵ Department for Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
¹⁶ Department of Neuroscience and Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, United States.
¹⁷ Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States.
¹⁸ Department of Biomedical Engineering, Yale University, New Haven, CT, United States.
¹⁹ Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States.
²⁰ Center for Animal MRI, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
²¹ Biomedical Research Imaging Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
²² Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
²³ Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
²⁴ Department of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
²⁵ Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
²⁶ Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, United States.
²⁷ Center for Neural Engineering, The Pennsylvania State University, University Park, PA, United States.

PMID: 40800991
PMCID: PMC12319733
DOI: 10.1162/IMAG.a.12

Charting the path in rodent functional neuroimaging

Alessandro Gozzi et al. Imaging Neurosci (Camb). 2025.

. 2025 May 28:3:IMAG.a.12.

doi: 10.1162/IMAG.a.12. eCollection 2025.

Authors

Affiliations

¹ Functional Neuroimaging Laboratory, Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, Rovereto, Italy.
² Center for Mind and Brain Sciences, University of Trento, Rovereto, Italy.
³ Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States.
⁴ Champalimaud Research, Champalimaud Foundation, Lisbon, Portugal.
⁵ Computational Brain Anatomy Laboratory, Cerebral Imaging Center, Douglas Mental Health University Institute, Montreal, Canada.
⁶ Integrated Program in Neuroscience, McGill University, Montreal, Canada.
⁷ Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States.
⁸ Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy.
⁹ Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrück Center for Molecular Medicine, Helmholtz Association of German Research Centers (HZ), Berlin, Germany.
¹⁰ Autism Center, Child Mind Institute, New York, NY, United States.
¹¹ IMT School for Advanced Studies, Lucca, Italy.
¹² Istituto Superiore di Sanità, Rome, Italy.
¹³ Department of Biomedical Engineering, Boston University, Boston, MA, United States.
¹⁴ Donders Institute for Brain, Behaviour, and Cognition, Radboud University, Nijmegen, The Netherlands.
¹⁵ Department for Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
¹⁶ Department of Neuroscience and Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, United States.
¹⁷ Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States.
¹⁸ Department of Biomedical Engineering, Yale University, New Haven, CT, United States.
¹⁹ Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States.
²⁰ Center for Animal MRI, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
²¹ Biomedical Research Imaging Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
²² Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
²³ Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
²⁴ Department of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
²⁵ Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
²⁶ Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, United States.
²⁷ Center for Neural Engineering, The Pennsylvania State University, University Park, PA, United States.

PMID: 40800991
PMCID: PMC12319733
DOI: 10.1162/IMAG.a.12

Abstract

Driven by a period of accelerated progress and recent technical breakthroughs, whole-brain functional neuroimaging in rodents offers exciting new possibilities for addressing basic questions about brain function and its alterations. In response to lessons learned from the human neuroimaging community, leading scientists and researchers in the field convened to address existing barriers and outline ambitious goals for the future. This article captures these discussions, highlighting a shared vision to advance rodent functional neuroimaging into an era of increased impact.

Keywords: anesthesia; awake; fMRI; fUSI; mouse; rat.

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Conflict of interest statement

The authors declare no conflict of interest.

References

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Charting the path in rodent functional neuroimaging

Affiliations

Charting the path in rodent functional neuroimaging

Authors

Affiliations

Abstract

Conflict of interest statement

References

Grants and funding

LinkOut - more resources

Full Text Sources