Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2025 Aug 13:14:e108470.
doi: 10.7554/eLife.108470.

Mimicking early life-forms in the lab

Affiliations
Editorial

Mimicking early life-forms in the lab

Maarten Lubbers et al. Elife. .

Abstract

Studying the growth of bacteria without cell walls in an artificial environment can shed new light on the proliferation of primitive life-forms billions of years ago.

Keywords: archaean eon; biofilms; evolutionary biology; microfossil morphology; microfossils; origin of life; protocells.

PubMed Disclaimer

Conflict of interest statement

ML, DC No competing interests declared

Figures

Figure 1.
Figure 1.. Using bacteria without cell walls to mimic the proliferation of early life-forms.
(A, B) Kanaparthi et al. engineered a bacterium called Exiguobacterium strain-Molly (EM) into a wall-deficient state called EM-P, and found that these cells proliferated by forming internal daughter cells (A, left), or by forming a string of external cells (A, right). The cells then formed biofilms (C), which subsequently transformed into honeycomb-shaped mats (D), which resemble some of the structures seen in microfossils.

Comment on

  • doi: 10.7554/eLife.98637

References

    1. Errington J, Mickiewicz K, Kawai Y, Wu LJ. L-form bacteria, chronic diseases and the origins of life. Philosophical Transactions of the Royal Society B. 2016;371:20150494. doi: 10.1098/rstb.2015.0494. - DOI - PMC - PubMed
    1. Kanaparthi D, Westall F, Lampe M, Zhu B, Boesen T, Scheu B, Klingl A, Schwille P, Lueders T. On the nature of the earliest known lifeforms. eLife. 2025;13:RP98637. doi: 10.7554/eLife.98637. - DOI
    1. Knauth LP. Temperature and salinity history of the Precambrian ocean: Implications for the course of microbial evolution. Palaeogeography, Palaeoclimatology, Palaeoecology. 2005;219:53–69. doi: 10.1016/j.palaeo.2004.10.014. - DOI
    1. Mercier R, Domínguez-Cuevas P, Errington J. Crucial role for membrane fluidity in proliferation of primitive cells. Cell Reports. 2012;1:417–423. doi: 10.1016/j.celrep.2012.03.008. - DOI - PubMed
    1. Schopf JW, Kitajima K, Spicuzza MJ, Kudryavtsev AB, Valley JW. SIMS analyses of the oldest known assemblage of microfossils document their taxon-correlated carbon isotope compositions. PNAS. 2018;115:53–58. doi: 10.1073/pnas.1718063115. - DOI - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources