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Review
. 2025 Jul 25;14(15):1153.
doi: 10.3390/cells14151153.

Rejuvenated Autologous Adult Stem Cells: Emerging Front Runners in the Fight Against Aging and Associated Diseases

An Yu  1 , Changguo Ma  1 , Min Hu  1
Affiliations
Review

Rejuvenated Autologous Adult Stem Cells: Emerging Front Runners in the Fight Against Aging and Associated Diseases

An Yu et al. Cells. .

Abstract

The growing global elderly population underscores the escalating importance of anti-aging interventions to combat age-related diseases and extend both health span and lifespan. Over the past decades, various anti-aging interventions have gained recognition, each with its unique set of advantages and limitations. Notably, the transplantation of rejuvenated autologous adult stem cells is standing out as a powerful strategy that holds significant promise in combating age-related functional decline and diseases. This review delves into our current biological insights into cellular rejuvenation and provides an overview of both pre-clinical and clinical experiences with autologous and allogeneic adult stem cell transplantations. It reinforces the concept that rejuvenated adult stem cells constitute a pivotal element in the quest for the fountain of youth. Additionally, we examine the technical challenges involved in obtaining and utilizing these rejuvenated adult stem cells.

Keywords: adult stem cells; autologous transplantation; cellular rejuvenation; cellular reprogramming.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Adult stem cell pool exhaustion during aging. Both activated adult stem cells and quiescent adult stem cells have their own issues that drive the stem cell pool exhaustion during aging.
Figure 2
Figure 2
Different reprogramming strategies to obtain autologous mesenchymal stem cells. Mesenchymal stem cells can either be obtained by autologous iPSCs differentiation or autologous fibroblasts reprogramming (dedifferentiation) toward multipotency.
See this image and copyright information in PMC

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