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Review
. 2025 Jul 29;14(15):1163.
doi: 10.3390/cells14151163.

Angiogenic Cell Precursors and Neural Cell Precursors in Service to the Brain-Computer Interface

Fraser C Henderson Sr  1   2 , Kelly Tuchman  2
Affiliations
Review

Angiogenic Cell Precursors and Neural Cell Precursors in Service to the Brain-Computer Interface

Fraser C Henderson Sr et al. Cells. .

Abstract

The application of artificial intelligence through the brain-computer interface (BCI) is proving to be one of the great advances in neuroscience today. The development of surface electrodes over the cortex and very fine electrodes that can be stereotactically implanted in the brain have moved the science forward to the extent that paralyzed people can play chess and blind people can read letters. However, the introduction of foreign bodies into deeper parts of the central nervous system results in foreign body reaction, scarring, apoptosis, and decreased signaling. Implanted electrodes activate microglia, causing the release of inflammatory factors, the recruitment of systemic inflammatory cells to the site of injury, and ultimately glial scarring and the encapsulation of the electrode. Recordings historically fail between 6 months and 1 year; the longest BCI in use has been 7 years. This article proposes a biomolecular strategy provided by angiogenic cell precursors (ACPs) and nerve cell precursors (NCPs), administered intrathecally. This combination of cells is anticipated to sustain and promote learning across the BCI. Together, through the downstream activation of neurotrophic factors, they may exert a salutary immunomodulatory suppression of inflammation, anti-apoptosis, homeostasis, angiogenesis, differentiation, synaptogenesis, neuritogenesis, and learning-associated plasticity.

Keywords: ACP; IL-8; M2 phenotype; NCP; NF-κB; NK cells; P75NTR; brain/AI interface; learning; progenitor cells; stem cells.

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Conflict of interest statement

Professor Henderson is a practicing academic neurosurgeon who serves as Chief Medical Officer and has stock in Hemostemix, Inc. Kelly Tuchman was paid for her time by Metropolitan Neurosurgery Group and has no conflict of interest. The potential conflicts of interest have been transparently disclosed and do not undermine the scientific validity of the work.

Figures

Figure 1
Figure 1
Natural killer (NK) cells recruited by angiogenic cell precursors (ACPs) suppress inflammation through release of anti-inflammatory cytokines, dendritic cell and monocyte maturation, and lysis of auto-aggressive T cells. Created in BioRender. Tuchman, K. (2025) https://BioRender.com/6rfoaiv.
Figure 2
Figure 2
Angiogenic cell precursors (ACPs) potentiate healing through expression of tissue regeneration factors such as the chemokine interleukin-8 (CXCL8), vascular endothelial growth factor (VEGF), and angiogenin. In addition to the robust presence of CD34+ in ACPs, the expressed CXCL8 recruits peripheral CD34+ precursor cells, further supporting angiogenesis. Created in BioRender. Tuchman, K. (2025) https://BioRender.com/w2cthsg.
Figure 3
Figure 3
Interleukin-8 (CXCL8) is expressed by angiogenic cell precursors (ACPs), and activates the canonical NF-κB pathway, resulting in gene transcription and protein synthesis necessary for memory formation and consolidation. Created in BioRender. Tuchman, K. (2025) https://BioRender.com/u2icrk5.
Figure 4
Figure 4
Neural progenitor cells (NCPs) have CXCR4 receptors and migrate towards CXCL12 released by injured tissue. NCPs promote the M2 (neuroprotective) macrophage phenotype, which release anti-inflammatory factors. The NCPs differentiate into neural, glial, or oligodendrocytic cells. Created in BioRender. Tuchman, K. (2025) https://BioRender.com/36j1vy7.
See this image and copyright information in PMC

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