Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2025 Aug 12;58(8):1880-1882.
doi: 10.1016/j.immuni.2025.07.019.

No STINGs attached: How APOE-Christchurch dampens Alzheimer's pathology

Leyla Anne Akay  1 , Li-Huei Tsai  2
Affiliations
Comment

No STINGs attached: How APOE-Christchurch dampens Alzheimer's pathology

Leyla Anne Akay et al. Immunity. .

Abstract

The "Christchurch" protective variant in the APOE gene has recently been identified, but its mechanisms of action remain unknown. In this issue of Immunity, Naguib and Lopez-Lee et al. provide evidence for the APOE-Christchurch variant suppressing microglial cGAS-STING responses and increasing clearance of pathological tau aggregates in mouse models of Alzheimer's disease.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests The authors declare no competing interests.

LinkOut - more resources