Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2025 Aug 13;25(1):1325.
doi: 10.1186/s12903-025-06697-6.

Efficacy comparison between dentofacial orthopedic treatment and adenotonsillectomy on children with obstructive sleep apnea and skeletal class II malocclusion: a retrospective study

Gang Yang #  1   2 , Anqi Liu #  3 , Jie Pan  4   2 , Yijie Zhao  4   2 , Liming Yu  4   2 , Liangyan Sun  1   2 , Xianqin Tong  4   2 , Yuanyuan Li  5   6 , Yuehua Liu  7   8
Affiliations
Comparative Study

Efficacy comparison between dentofacial orthopedic treatment and adenotonsillectomy on children with obstructive sleep apnea and skeletal class II malocclusion: a retrospective study

Gang Yang et al. BMC Oral Health. .

Abstract

Objective: This study aims to evaluate the effects of dentofacial orthopedic treatment (DOT) and adenotonsillectomy (AT) in Obstructive Sleep Apnea (OSA) children with skeletal Class II malocclusion and adenotonsillar hypertrophy (ATH), focusing on changes in sleep respiratory function, anatomic and aerodynamic characteristics of upper airway (UA).

Methods: In this retrospective study, 38 OSA children (mean age: 8.42 years, 15 females and 23 males) were included consecutively. Patients were categorized into two groups: DOT group (n = 20) and AT group (n = 18). Baseline (T0) and follow-up (T1) assessments involved polysomnography and radiological examinations to evaluate improvements in sleep quality as well as changes in craniofacial morphology and UA variables. Aerodynamic parameters such as airflow velocity, airway resistance, and wall shear stress were quantified using computational fluid dynamics.

Results: In the comparative analysis of sleep respiratory functions, there were no significant differences in apnea-hypopnea index changes between the treatment groups (DOT group: -3.72/h, AT group: -3.32/h, P = 0.600). In the DOT group, UA's volume average enlargements were observed in the nasopharynx, palatopharynx, glossopharynx, and hypopharynx by 54.5%, 41.6%, 34.0%, and 22.5%, respectively. In comparison, the AT group showed enlargements of 66.0%, 20.1%, 62.9%, and - 1.0%, respectively. In terms of UA aerodynamic characteristics, there were no significant differences between two groups.

Conclusions: In OSA children with skeletal Class II malocclusion and ATH, DOT as a non-invasive approach, has shown improvements in respiratory function comparable to AT, as evidenced by changes in the UA's anatomical and aerodynamic characteristics.

Keywords: Adenotonsillectomy; Children; Computational fluid dynamics; Dentofacial orthopedic treatment; OSA; Skeletal class II malocclusion.

PubMed Disclaimer

Conflict of interest statement

Declarations. Ethics approval and consent to participate: This retrospective study was approved by the Research Ethics Committee of Shanghai Stomatological Hospital (approval no. 2023/012). All patients and their parents signed informed consent and authorizing the use of the examinations for research purposes. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. Trial registration: This study was registered with the Chinese Clinical Trial Registry (ChiCTR), registration number ChiCTR2500102383.

Figures

Fig. 1
Fig. 1
A dentofacial orthopedic treatment (MAA + RME): (B) Adenotonsillectomy
Fig. 2
Fig. 2
Volumetric assessments of the nasopharynx, palatopharynx, glossopharynx, and hypopharynx using the reconstructed 3D surface model. P1 the posterior nasal spine plane; (P2) the uvula tip plane; (P3) the epiglottis tip plane; (P4) the inferior border of the fourth cervical vertebra
Fig. 3
Fig. 3
Workflow of the CFD simulations
Fig. 4
Fig. 4
Aerodynamic parameter comparison in the AT group at T0 and T1. A-D for T0 (A): volume rendering, (B): WSS, (C): pressure, (D): velocity); (E-H) for T1
Fig. 5
Fig. 5
Aerodynamic parameter comparison in the DOT group at T0 and T1. A-D for T0 (A): volume rendering, (B): WSS, (C): pressure, (D): velocity); (E-H) for T1
Fig. 6
Fig. 6
Comparison of velocity distribution across P1-P4 at T0 and T1 in the AT group. A, T0; (B), T1
Fig. 7
Fig. 7
Comparison of velocity distribution across P1-P4 at T0 and T1 in the DOT group. A, T0; (B), T1
See this image and copyright information in PMC

References

    1. Gottlieb D, Punjabi N. Diagnosis and management of obstructive sleep apnea: a review. JAMA. 2020;323(14):1389–400. - PubMed
    1. Mason G, Lokhandwala S, Riggins T, Spencer R. Sleep and human cognitive development. Sleep Med Rev. 2021;57: 101472. - PMC - PubMed
    1. Lo Bue A, Salvaggio A, Insalaco G. Obstructive sleep apnea in developmental age. A narrative review. Eur J Pediatrics. 2020;179(3):357–65. - PubMed
    1. Kim J, Bhattacharjee R, Dayyat E, Snow AB, Kheirandish-Gozal L, Goldman JL, et al. Increased cellular proliferation and inflammatory cytokines in tonsils derived from children with obstructive sleep apnea. Pediatr Res. 2009;66(4):423–8. - PMC - PubMed
    1. Marcus C, Brooks L, Draper K, Gozal D, Halbower A, Jones J, et al. Diagnosis and management of childhood obstructive sleep apnea syndrome. Pediatrics. 2012;130(3):e714–55. - PubMed

Publication types

MeSH terms

LinkOut - more resources