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. 2025 Aug 5;13(15):1917.
doi: 10.3390/healthcare13151917.

Reframing Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Biological Basis of Disease and Recommendations for Supporting Patients

Priya Agarwal  1 , Kenneth J Friedman  2
Affiliations

Reframing Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Biological Basis of Disease and Recommendations for Supporting Patients

Priya Agarwal et al. Healthcare (Basel). .

Abstract

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a worldwide challenge. There are an estimated 17-24 million patients worldwide, with an estimated 60 percent or more who have not been diagnosed. Without a known cure, no specific curative medication, disability lasting years to being life-long, and disagreement among healthcare providers as to how to most appropriately treat these patients, ME/CFS patients are in need of assistance. Appropriate healthcare provider education would increase the percentage of patients diagnosed and treated; however, in-school healthcare provider education is limited. To address the latter issue, the New Jersey Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Association (NJME/CFSA) has developed an independent, incentive-driven, learning program for students of the health professions. NJME/CFSA offers a yearly scholarship program in which applicants write a scholarly paper on an ME/CFS-related topic. The efficacy of the program is demonstrated by the 2024-2025 first place scholarship winner's essay, which addresses the biological basis of ME/CFS and how the healthcare provider can improve the quality of life of ME/CFS patients. For the reader, the essay provides an update on what is known regarding the biological underpinnings of ME/CFS, as well as a medical student's perspective as to how the clinician can provide care and support for ME/CFS patients. The original essay has been slightly modified to demonstrate that ME/CFS is a worldwide problem and for publication.

Keywords: advocacy; chronic fatigue syndrome; chronic illness; myalgic encephalomyelitis; patient-centered care.

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Conflict of interest statement

K.J.F., as Chair of the NJME/CFSA Medical Scholar Program initially proposed the design of this study to the Medical Scholarship Committee of NJME/CFSA.As an eligible applicant for the scholarship, P.A. wrote the initial draft of the manuscript which resulted in her winning a $5000 tuition remission credited to her tuition account at the medical school she attends.

References

    1. Lim E.J., Ahn Y.C., Jang E.S., Lee S.W., Lee S.H., Son C.G. Systematic review and meta-analysis of the prevalence of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) J. Transl. Med. 2020;18:100. doi: 10.1186/s12967-020-02269-0. - DOI - PMC - PubMed
    1. Cullinan J., Pheby D.F.H., Araja D., Berkis U., Brenna E., de Korwin J.D., Gitto L., Hughes D.A., Hunter R.M., Trepel D., et al. Perceptions of European ME/CFS Experts Concerning Knowledge and Understanding of ME/CFS among Primary Care Physicians in Europe: A Report from the European ME/CFS Research Network (EUROMENE) Medicina. 2021;57:208. doi: 10.3390/medicina57030208. - DOI - PMC - PubMed
    1. Graves B.S., Patel M., Newgent H., Parvathy G., Nasri A., Moxam J., Gill G.S., Sawhney V., Gupta M. Chronic Fatigue Syndrome: Diagnosis, Treatment, and Future Direction. Cureus. 2024;16:e70616. doi: 10.7759/cureus.70616. - DOI - PMC - PubMed
    1. Sandler C.X., Lloyd A.R. Chronic fatigue syndrome: Progress and possibilities. Med. J. Aust. 2020;212:428–433. doi: 10.5694/mja2.50553. - DOI - PubMed
    1. Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Board on the Health of Select Populations, Institute of Medicine . Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness. National Academies Press (US); Washington, DC, USA: 2015. The National Academies Collection: Reports funded by National Institutes of Health. - DOI

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