Exacerbation control in chronic obstructive pulmonary disease with tezepelumab: insights from the COURSE trial
- PMID: 40809200
- PMCID: PMC12340292
- DOI: 10.21037/jtd-2025-769
Exacerbation control in chronic obstructive pulmonary disease with tezepelumab: insights from the COURSE trial
Keywords: Clinical trial; chronic obstructive pulmonary disease (COPD); monoclonal antibody; tezepelumab; thymic stromal lymphopoietin (TSLP).
Conflict of interest statement
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://jtd.amegroups.com/article/view/10.21037/jtd-2025-769/coif). The authors have no conflicts of interest to declare.
Comment on
-
Efficacy and safety of tezepelumab versus placebo in adults with moderate to very severe chronic obstructive pulmonary disease (COURSE): a randomised, placebo-controlled, phase 2a trial.Lancet Respir Med. 2025 Jan;13(1):47-58. doi: 10.1016/S2213-2600(24)00324-2. Epub 2024 Dec 6. Lancet Respir Med. 2025. PMID: 39653044 Clinical Trial.
References
-
- Singh D, Brightling CE, Rabe KF, et al. Efficacy and safety of tezepelumab versus placebo in adults with moderate to very severe chronic obstructive pulmonary disease (COURSE): a randomised, placebo-controlled, phase 2a trial. Lancet Respir Med 2025;13:47-58. 10.1016/S2213-2600(24)00324-2 - DOI - PubMed
-
- Saber Cherif L, Devilliers MA, Perotin JM, et al. Airway epithelial TSLP production is increased in COPD patients. Eur Respir J 2023;62:PA611.
Publication types
LinkOut - more resources
Full Text Sources