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. 2025 Jul 31;17(7):4512-4523.
doi: 10.21037/jtd-2024-2273. Epub 2025 Jul 9.

Anesthesia management for lung transplant in children with obliterated bronchiolitis after hematopoietic stem cell transplantation: a single-center experience

Ping Gao #  1 , Xinchen Tao #  1 , Ge Luo #  1 , Yuanyuan Yao  1 , Congcong Chen  1 , Lifang Zhang  1 , Shui Yu  1 , Ming Gong  1 , Man Huang  2 , Jingyu Chen  3 , Min Yan  1
Affiliations

Anesthesia management for lung transplant in children with obliterated bronchiolitis after hematopoietic stem cell transplantation: a single-center experience

Ping Gao et al. J Thorac Dis. .

Abstract

Background: Lung transplantation (LTx) is the definitive treatment for patients with end-stage lung diseases, but its application in pediatrics is limited by donor scarcity and surgical complexity. There is a general lack of experience and consensus on anesthetic management during LTx in children with bronchiolitis obliterans syndrome (BOS). We summarized the data of children undergoing LTx with BOS after hematopoietic stem cell transplantation (HSCT) at The Second Affiliated Hospital of Zhejiang University School of Medicine (SAHZU) to devise an anesthetic management strategy and describe practical experience.

Methods: Children with BOS who underwent LTx at SAHZU from January 2021 to September 2023 were reviewed. Data on demographics, perioperative clinical parameters, and outcomes were collected and recorded. Transesophageal echocardiography (TEE) guided the dynamic evaluation of cardiac function, volume management, and pulmonary vascular anastomosis. Pulmonary artery catheters (PACs) were used to monitor pulmonary artery pressure (PAP).

Results: Ten children with BOS post-HSCT underwent LTx, including eight males and two females. One patient had a single LTx, and the others had double LTx. All children received allogeneic red blood cell (RBC) infusion. Three received continuous renal replacement therapy (CRRT) during the operation. Postoperative mechanical ventilation time was 2 (IQR, 2-24) days. Extracorporeal membrane oxygenation (ECMO) time was 12 (IQR, 6-12) hours. Four patients developed acute kidney injury (AKI) within 48 hours, and primary graft dysfunction grade 3 (PGD3) occurred in 10% within 48-72 hours. Intensive care unit (ICU) stay was 9 (IQR, 6-40) days, and the 30-day survival rate was 100%.

Conclusions: Preoperative evaluation, volume management, hemodynamic monitoring, TEE, and ECMO application are the key points that anesthesiologists should pay attention to in such cases.

Keywords: Bronchiolitis obliterans syndrome (BOS); extracorporeal membrane oxygenation (ECMO); lung transplantation (LTx); transesophageal echocardiography (TEE).

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://jtd.amegroups.com/article/view/10.21037/jtd-2024-2273/coif). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Central VA-ECMO on pediatric LTx. LTx, lung transplantation; VA-ECMO, veno-arterial extracorporeal membrane oxygenation.
See this image and copyright information in PMC

References

    1. Khush KK, Hsich E, Potena L, et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-eighth adult heart transplantation report - 2021; Focus on recipient characteristics. J Heart Lung Transplant 2021;40:1035-49. 10.1016/j.healun.2021.07.015 - DOI - PMC - PubMed
    1. Christie JD, Edwards LB, Kucheryavaya AY, et al. The Registry of the International Society for Heart and Lung Transplantation: twenty-seventh official adult lung and heart-lung transplant report--2010. J Heart Lung Transplant 2010;29:1104-18. 10.1016/j.healun.2010.08.004 - DOI - PubMed
    1. Mendeloff EN. The history of pediatric heart and lung transplantation. Pediatr Transplant 2002;6:270-9. 10.1034/j.1399-3046.2002.00217.x - DOI - PubMed
    1. Chambers DC, Cherikh WS, Harhay MO, et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-sixth adult lung and heart-lung transplantation Report-2019; Focus theme: Donor and recipient size match. J Heart Lung Transplant 2019;38:1042-55. 10.1016/j.healun.2019.08.001 - DOI - PMC - PubMed
    1. Yue B, Wu B, Zhang J, et al. Pediatric lung transplantation in the largest lung transplantation center of China: embarking on a long road. Sci Rep 2020;10:12471. 10.1038/s41598-020-69340-0 - DOI - PMC - PubMed

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