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Case Reports
. 2025 Jul 13;17(7):e87846.
doi: 10.7759/cureus.87846. eCollection 2025 Jul.

Extrafollicular Variant of the Common Adenomatoid Odontogenic Tumour: A Rare Case Report

Bhavani N Sangala  1 , Kirti Buva  1 , Saudamini More  2 , Amit Patil  3 , Sandhya Rani Akula  4 , Sanpreet S Sachdev  1
Affiliations
Case Reports

Extrafollicular Variant of the Common Adenomatoid Odontogenic Tumour: A Rare Case Report

Bhavani N Sangala et al. Cureus. .

Abstract

Adenomatoid odontogenic tumour (AOT) is a benign epithelial neoplasm of odontogenic origin, typically seen in young female patients and commonly associated with impacted canines in the anterior maxilla. The extrafollicular variant, which is not associated with unerupted teeth, is relatively rare and may present diagnostic challenges due to its similarity with other odontogenic cysts or tumours. This report presents a case of a 23-year-old female patient with a gradually enlarging swelling in the anterior maxilla. Radiographic imaging revealed a well-defined radiolucency with root resorption and displacement of adjacent teeth. Histopathological examination confirmed the diagnosis of extrafollicular AOT. The lesion was managed successfully with conservative surgical excision, and no recurrence was noted during a two-year follow-up. This case highlights the importance of integrating clinical, radiological, and histopathological findings for accurate diagnosis and appropriate management of this rare AOT variant.

Keywords: adenomatoid odontogenic tumour; anterior maxilla; extrafollicular variant; odontogenic neoplasm; root resorption.

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Conflict of interest statement

Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Clinical appearance of the swelling
A) Swelling (indicated by the arrow) in the middle third of the face; B) Intraoral swelling in the maxillary anterior region (lesion indicated by the arrow).
Figure 2
Figure 2. Orthopantomogram showing solitary well-defined radiolucency with a cortical margin (lesion indicated by the arrow)
Figure 3
Figure 3. Excised ovoid tumour mass
Figure 4
Figure 4. Hemotoxylin and Eosin (H &E) staining
A) Scanner view showing cystic lumen lined by cystic lining and tumor nodules (H & E stain, 4x magnification); B) Low power view exhibiting cuboidal to spindle-shaped cells arranged in whorls, ducts, sheets, and cords (H & E stain, 10x magnification)
Figure 5
Figure 5. Hematoxylin and Eosin (H & E) staining of the stroma
A) Cystic lumen lined by two to three layers of odontogenic epithelium; B) Large areas of eosinophilic secretary material and focal collections of round, basophilic calcifications with eosinophilic droplets. (H & E stain, 10x magnification).
See this image and copyright information in PMC

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