Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2025 Jul 30:19:1614320.
doi: 10.3389/fncel.2025.1614320. eCollection 2025.

Editorial: Pathogenic potassium channel variants in neurological disorders: from functional analysis to personalized pharmacological approaches

Ilenio Servettini  1 , Luca Guglielmi  2 , Luigi Sforna  3 , Luigi Catacuzzeno  3
Affiliations
Editorial

Editorial: Pathogenic potassium channel variants in neurological disorders: from functional analysis to personalized pharmacological approaches

Ilenio Servettini et al. Front Cell Neurosci. .
No abstract available

Keywords: correlation genotype-phenotype; neurological disorder; pathogenic variant; potassium channel; precision medicine.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Comment on

  • Editorial on the Research Topic Pathogenic potassium channel variants in neurological disorders: from functional analysis to personalized pharmacological approaches

References

    1. Allen N. M., Weckhuysen S., Gorman K., King M. D., Lerche H. (2020). Genetic potassium channel-associated epilepsies: clinical review of the K(v) family. Eur. J. Paediatr. Neurol. 24, 105–116. 10.1016/j.ejpn.2019.12.002 - DOI - PubMed
    1. Ambrosini E., Sicca F., Brignone M. S., D'Adamo M. C., Napolitano C., Servettini I., et al. (2014). Genetically induced dysfunctions of Kir2.1 channels: implications for short QT3 syndrome and autism-epilepsy phenotype. Hum. Mol. Genet. 23, 4875–4886. 10.1093/hmg/ddu201 - DOI - PMC - PubMed
    1. Ambrosino P., Ragona F., Mosca I., Vannicola C., Canafoglia L., Solazzi R., et al. (2023). A novel KCNC1 gain-of-function variant causing developmental and epileptic encephalopathy: “Precision medicine” approach with fluoxetine. Epilepsia 64, 148–155. 10.1111/epi.17656 - DOI - PubMed
    1. Bar C., Barcia G., Jennesson M., Le Guyader G., Schneider A., Mignot C., et al. (2020). Expanding the genetic and phenotypic relevance of KCNB1 variants in developmental and epileptic encephalopathies: 27 new patients and overview of the literature. Hum. Mutat. 41, 69–80. 10.1002/humu.23915 - DOI - PubMed
    1. Cheng P., Qiu Z., Du Y. (2021). Potassium channels and autism spectrum disorder: an overview. Int. J. Dev. Neurosci. 81, 479–491. 10.1002/jdn.10123 - DOI - PubMed

Publication types

LinkOut - more resources