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. 2025 Aug 14:e17124.
doi: 10.1002/advs.202417124. Online ahead of print.

Cuproptosis Signature Would Reveal the Acute-Remitting Pattern in Patients with Neuromyelitis Optica Spectrum Disorder

Peidong Liu  1   2 , Ruoyu Li  1 , Xinlin Wang  2 , Hui Li  1 , Huiru Hu  3 , Ang Shen  1 , Wenping Zhu  1 , Jiali Pan  4 , Yanmeng Xing  5 , Weiming Xia  1 , Henan Jiao  2 , Di Chen  2 , Lixin Wu  2 , Li Liu  6 , Ju Liu  1 , Bin Yu  2 , Xianzhi Liu  2 , Hongbo Liu  1
Affiliations

Cuproptosis Signature Would Reveal the Acute-Remitting Pattern in Patients with Neuromyelitis Optica Spectrum Disorder

Peidong Liu et al. Adv Sci (Weinh). .

Abstract

The acute-remitting course (the time interval from remission to the next relapse) is a distinct signature of neuromyelitis optica spectrum disorder (NMOSD), which harms patients and perplexes physicians. However, clinically actionable biomarkers to anticipate NMOSD relapse timing are unavailable. Recently, it is found that Cuproptosis-related genes would have an impact on the acute-remitting course in patients with aquaporin-4 (AQP4)-immunoglobulin G antibody positive NMOSD. A machine learning-based algorithm is developed to construct a consensus Cuproptosis-related prognosis risk (CRPR) model, followed by training a proportional hazards model to divide patients with NMOSD into high/low relapse risk groups. The CRPR is related to the clinical symptoms of patients with NMOSD. Finally, a nomogram is created using CRPR to predict the possibility of relapse in new cases of NMOSD. This prediction model can assist physicians and help develop appropriate interventions to prevent disease relapse.

Keywords: NMOSD; acute‐remitting course; cuprotosis.

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References

    1. a) C. Qin, M. Chen, M.‐H. Dong, S. Yang, H. Zhang, Y.‐F. You, L.‐Q. Zhou, Y.‐H. Chu, Y. Tang, X.‐W. Pang, L.‐J. Wu, D.‐S. Tian, W. Wang, Brain 2024, 147, 163;
    1. b) V. Papp, M. Magyari, O. Aktas, T. Berger, S. A. Broadley, P. Cabre, A. Jacob, J.‐I. Kira, M. I. Leite, R. Marignier, K. Miyamoto, J. Palace, A. Saiz, M. Sepulveda, O. Sveinsson, Z. Illes, Neurology 2021, 96, 59;
    1. c) S. Jarius, F. Paul, B. G. Weinshenker, M. Levy, H. J. Kim, B. Wildemann, Nat. Rev. Dis. Primers 2020, 6, 85.
    1. E. Carnero Contentti, J. Correale, J. Neuroinflamm. 2021, 18, 208.
    1. H. Y. F. Yong, J. M. Burton, Curr. Neurol. Neurosci. Rep. 2023, 23, 489.