Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Aug 14.
doi: 10.1007/s00261-025-05134-0. Online ahead of print.

Diagnostic performance of Node-RADS on MRI for a standardized assessment of lymph node metastasis in ovarian cancer

Yuhang Liu  1 , Yuqiao Zhang  1 , Yunyue Tan  2 , Ao Zhou  1 , Xin Feng  1 , Furong Lv  3 , Zhibo Xiao  4
Affiliations

Diagnostic performance of Node-RADS on MRI for a standardized assessment of lymph node metastasis in ovarian cancer

Yuhang Liu et al. Abdom Radiol (NY). .

Abstract

Objective: The Node-RADS score was proposed and provided a standardized, comprehensive assessment of lymph nodes (LNs), accounting for both size and configuration criteria. This study aimed to evaluate the diagnostic performance of the Node-RADS in LN metastasis of ovarian cancer (OC).

Methods: From December 2018 to April 2023, 81 OC patients who underwent MRI and debulking surgery were included. The likelihood of LN metastasis was assessed by the Node-RADS with MRI. The chi-square test and Fisher's exact test were used to assess the differences in size and configuration between LNs with and without metastasis. The diagnostic performance of Node-RADS and its different criteria for LN metastasis was assessed with receiver operating characteristic (ROC) and area under the curve (AUC).

Results: Among all Node-RADS evaluation criteria, textural changes had the best performance with a sensitivity of 84.6%, a specificity of 78.7%, and a Youden's index of 0.63. At the LN level, the incidence of LN metastasis with Node-RADS scores 1, 2, 3, 4, and 5 was 3.2%, 4.5%, 13.0%, 85.7%, and 86.7%, respectively. The best performance in assessing LN status was observed at Node-RADS scores > 3, with sensitivity, specificity, and Youden's index of 73.1%, 97.8%, and 0.71, respectively. In addition, at the patient and LN levels, the AUC for Node-RADS assessment of LNs was 0.869 and 0.895, respectively.

Conclusion: Node-RADS could be an appropriate choice for structured reporting of LN metastasis in OC. The diagnostic performance of LN metastasis in OC at a Node-RADS score > 3 was satisfactory.

Keywords: Lymph node metastasis; MRI; Node-RADS; Ovarian cancer.

PubMed Disclaimer

Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests.

References

    1. Prat J. New insights into ovarian cancer pathology. Ann Oncol. 2012;23:x111–7. https://doi.org/10.1093/annonc/mds300 - DOI - PubMed
    1. Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74:229–63. https://doi.org/10.3322/caac.21834 - DOI - PubMed
    1. Bayraktar E, Chen S, Corvigno S, Liu J, Sood AK. Ovarian cancer metastasis: looking beyond the surface. Cancer Cell. 2024;42:1631–6. https://doi.org/10.1016/j.ccell.2024.08.016 - DOI - PubMed
    1. Fournier M, Stoeckle E, Guyon F, Brouste V, Thomas L, MacGrogan G, et al. Lymph node involvement in epithelial ovarian cancer: sites and risk factors in a series of 355 patients. Int J Gynecol Cancer: Off J Int Gynecol Cancer Soc. 2009;19:1307–13. https://doi.org/10.1111/IGC.0b013e3181b8a07c - DOI
    1. Berek JS, Renz M, Kehoe S, Kumar L, Friedlander M. Cancer of the ovary, fallopian tube, and peritoneum: 2021 update. Int J Gynecol Obstet. 2021;155:61–85. https://doi.org/10.1002/ijgo.13878 - DOI