The ins and outs of circulating DNA

W H Adrian Tsui^{1

2

3}, Y M Dennis Lo^{1

2

3

4}

Affiliations

¹ Centre for Novostics, Hong Kong Science Park, Pak Shek Kok, New Territories, Hong Kong SAR, China.
² Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.
³ Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.
⁴ State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.

Comment

W H Adrian Tsui et al. Science. 2025.

. 2025 Aug 14;389(6761):683-684.

doi: 10.1126/science.aea0555. Epub 2025 Aug 14.

W H Adrian Tsui^{1

2

3}, Y M Dennis Lo^{1

2

3

4}

¹ Centre for Novostics, Hong Kong Science Park, Pak Shek Kok, New Territories, Hong Kong SAR, China.
² Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.
³ Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.
⁴ State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.

Abstract

DNA sequestered in circulating platelets could inform early tumor diagnosis.

Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA.
Murphy L, Inchauspé J, Valenzano G, Holland P, Sousos N, Belnoue-Davis HL, Li R, Jooss NJ, Benlabiod C, Murphy E, Etzioni Z, Shepherd E, Denly L, Biswas S, Chen L, O'Sullivan J, Rimmer MP, Khan AO, Karali CS, Nasreddin N, Hitchcock IS, Koupenova M, Kriaucionis S, Hughes JR, O'Neill E, Vatish M, Rees P, Leedham S, Desborough M, Mead AJ, Schuster-Böckler B, Gregory CD, Psaila B. Murphy L, et al. Science. 2025 Aug 14;389(6761):eadp3971. doi: 10.1126/science.adp3971. Epub 2025 Aug 14. Science. 2025. PMID: 40811534