Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Oct;115(10):1584-1588.
doi: 10.2105/AJPH.2025.308209. Epub 2025 Aug 14.

Implementation of Doxy-PEP in a Diverse Sexual Health Program in Northern Manhattan: The Doxy-Care Study

Simian Huang  1 , Caroline Carnevale  1 , Natalie Neu  1 , Joshua Klein  1 , Daniela Quigee  1 , Edward Perez  1 , Lauren Burrell  1 , Kathrine Meyers  1 , Jacob McLean  1 , Magdalena E Sobieszczyk  1 , Delivette Castor  1 , Jason Zucker  1
Affiliations

Implementation of Doxy-PEP in a Diverse Sexual Health Program in Northern Manhattan: The Doxy-Care Study

Simian Huang et al. Am J Public Health. 2025 Oct.

Abstract

This prospective cohort study evaluated the real-world effectiveness of doxycycline postexposure prophylaxis use in reducing bacterial sexually transmitted infections (STIs) within a diverse urban sexual health program. Propensity-matched analyses showed significant STI reductions, particularly in rectal Chlamydia trachomatis infections, among early adopters. Uptake was disproportionately higher in non-Hispanic White individuals and those more engaged in care. Findings emphasize the need for targeted outreach to improve care engagement and equitable access to this STI prevention strategy. (Am J Public Health. 2025;115(10):1584-1588. https://doi.org/10.2105/AJPH.2025.308209).

PubMed Disclaimer

References

    1. Bachmann LH , Barbee LA , Chan P , et al. CDC clinical guidelines on the use of doxycycline postexposure prophylaxis for bacterial sexually transmitted infection prevention, United States, 2024 . MMWR Recomm Rep. 2024. ; 73 ( 2 ): 1 – 8 . 10.15585/mmwr.rr7302a1 - DOI - PMC - PubMed
    1. Carter G , Tavares T. PrEP prescription in Indiana 2017‒2022: implications for clinical practice . Res Nurs Health. 2024. ; 47 ( 1 ): 49 – 59 . 10.1002/nur.22354 - DOI - PubMed
    1. Pleuhs B , Quinn KG , Walsh JL , Petroll AE , John SA. Health care provider barriers to HIV pre-exposure prophylaxis in the United States: a systematic review . AIDS Patient Care STDS. 2020. ; 34 ( 3 ): 111 – 123 . 10.1089/apc.2019.0189 - DOI - PMC - PubMed
    1. Kamitani E , Johnson WD , Wichser ME , Adegbite AH , Mullins MM , Sipe TA. Growth in proportion and disparities of HIV PrEP use among key populations identified in the United States national goals: systematic review and meta-analysis of published surveys . J Acquir Immune Defic Syndr. 2020. ; 84 ( 4 ): 379 – 386 . 10.1097/QAI.0000000000002345 - DOI - PMC - PubMed
    1. New York City Department of Health and Mental Hygiene, Bureau of Hepatitis, HIV, and Sexually Transmitted Infections . Sexually transmitted infections surveillance report, 2023 . December 2024. . Available at: https://www.nyc.gov/assets/doh/downloads/pdf/std/sti-2023-report.pdf . Accessed February 15, 2025.

LinkOut - more resources