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. 2025 Aug 14:e00951.
doi: 10.1002/cbdv.202500951. Online ahead of print.

Secondary Metabolites of Mansonia gagei and Their Potential Anti-dengue Properties

Huong Thi Thu Le  1 , Yusuke Hioki  2 , Truong Lam Tuong  3 , Vu Thi Bich Hau  4 , Nguyen Thi Thu Thuy  4 , Warinthorn Chavasiri  5 , Masaki Kita  2 , Thi Kha Uyen Tran  6 , Thanh-Hoa Vo  6   7 , Thi-Anh-Tuyet Le  8
Affiliations

Secondary Metabolites of Mansonia gagei and Their Potential Anti-dengue Properties

Huong Thi Thu Le et al. Chem Biodivers. .

Abstract

Three undescribed compounds, including compounds 1 and 2 with a bicyclo[3.2.1]octane skeleton, along with a coumarin derivative (compound 3) and seven known compounds (4-10), were isolated from the heartwood of Mansonia gagei. To our knowledge, compounds 6-8 are reported for the first time from the Mansonia genus. The structures of these compounds were determined through high-resolution electrospray ionization mass spectrometry, nuclear magnetic resonance spectroscopic analysis, and density functional theory calculations. The antiviral activity of isolated compounds was assessed against dengue virus serotype DENV1, indicating that compound 2 exhibited potent anti-dengue activity with a 50% Plaque Reduction Neutralization Test value of 17.47 µM.

Keywords: Mansonia gagei; anti‐dengue activity; coumarins; sesquiterpenoids.

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References

    1. K. H. Changal, A. H. Raina, A. Raina, et al., “Differentiating Secondary From Primary Dengue Using IgG to IgM Ratio in Early Dengue: An Observational Hospital Based Clinico‐Serological Study From North India,” BMC Infectious Diseases [Electronic Resource] 16 (2016).
    1. R. Shukla, R. Ahuja, H. Beesetti, et al., “Sinococuline, A Bioactive Compound of Cocculus hirsutus Has Potent Anti‐dengue Activity,” Scientific Reports 13 (2023): 1026.
    1. N. Singh and S. S. Yadav, “Anti‐dengue Therapeutic Potential of Tinospora Cordifolia and Its Bioactives,” Journal of Ethnopharmacology 330 (2024): 118242.
    1. N. U. A. Mohsin, M. Irfan, and S. Qamar, “Current Advancements for New Drug Discovery against Dengue Virus: A Review (2015 – 2020),” Pharmaceutical Chemistry Journal 57 (2023): 932–951.
    1. S N. Dighe, O'. Ekwudu, K. Dua, D. K. Chellappan, P L. Katavic, and T A. Collet, “Recent Update on Anti‐dengue Drug Discovery,” European Journal of Medicinal Chemistry 176 (2019): 431–455.

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