tsRNADisease: a manually curated database of tsRNAs associated with human disease

Abstract

tRNA-derived small RNAs (tsRNAs), as a class of regulatory small noncoding RNA, have been implicated in a wide variety of human diseases. Large amounts of tsRNA-disease associations have been identified in recent years from accumulating studies. However, repositories for cataloging the detailed information on tsRNA-disease associations are scarce. In this study, we provide a tsRNADisease database by integrating experimentally and computationally supported tsRNA-disease associations from manual curation of literatures and other related resources. tsRNADisease contains 5571 manually curated associations between 4759 tsRNAs and 166 diseases with experimental evidence from 346 studies. In addition, it also contains 5013 predicted associations between 1297 tsRNAs and 111 diseases. tsRNADisease provides a user-friendly interface to browse, retrieve, and download data conveniently. This database can improve our understanding of tsRNA deregulation in diseases and serve as a valuable resource for investigating the mechanism of disease-related tsRNAs. tsRNADisease is freely available at http://www.compgenelab.info/tsRNADisease.

Keywords: Cancer; Data Integration; Database; Disease; tsRNA.