Localization of indomethacin induced inhibition of oxygen consumption in mitochondria of the guinea pig gastric mucosa
- PMID: 4081321
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Localization of indomethacin induced inhibition of oxygen consumption in mitochondria of the guinea pig gastric mucosa
Res Commun Chem Pathol Pharmacol.
1985 Nov.
Abstract
The effect of indometacin-Na-trihydrate on oxygen consumption was studied in isolated mitochondria of the guinea pig gastric mucosa. Using various substrates with or without inhibitors it was possible to localize the inhibitory effect on or in the vicinity of complexes I and III of the respiratory chain. Effective concentrations of indometacin were within the range of gastric mucosal concentrations reached with submaximal ulcerogenic doses.
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