Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Nov;70(11):609-610.
doi: 10.1038/s10038-025-01384-4. Epub 2025 Aug 14.

Why are men taller than women?: Genetic and hormonal factors involved in sex differences in human height

Maki Fukami  1 , Tsutomu Ogata  2   3 , Atsushi Hattori  4
Affiliations

Why are men taller than women?: Genetic and hormonal factors involved in sex differences in human height

Maki Fukami et al. J Hum Genet. 2025 Nov.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Factors implicated in the sex difference in height. Berry et al. estimated the contribution of sex hormones and sex chromosomes to sexual dimorphism in height from population-based cohort data [7]. The authors assumed that SHOX accounts for a certain proportion of the sex chromosome effect. Ogata et al. estimated the effect size of sex hormones and sex chromosomes from the clinical data of patients with disorders of sex development (DSD) [9]
See this image and copyright information in PMC

References

    1. Ogata T, Hattori A, Fukami M. SHOX and sex difference in height: a hypothesis. Endocr J. 2025;72:37–42. - DOI - PMC - PubMed
    1. Naqvi S, Godfrey AK, Hughes JF, Goodheart ML, Mitchell RN, Page DC. Conservation, acquisition, and functional impact of sex-biased gene expression in mammals. Science. 2019;365:eaaw7317. - DOI - PMC - PubMed
    1. Marchini A, Ogata T, Rappold GA. A track record on SHOX: from basic research to complex models and therapy. Endocr Rev. 2016;37:417–48. - DOI - PMC - PubMed
    1. Balaton BP, Brown CJ. Escape artists of the X chromosome. Trends Genet. 2016;32:348–59. - DOI - PubMed
    1. Tukiainen T, Villani AC, Yen A, Rivas MA, Marshall JL, Satija R, et al. Landscape of X chromosome inactivation across human tissues. Nature. 2017;550:244–8. - DOI - PMC - PubMed

LinkOut - more resources