Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2025 Aug 14;29(1):356.
doi: 10.1186/s13054-025-05603-4.

Volatile sedation in critically ills adults undergoing mechanical ventilation: not all inhaled sedatives are equivalent!

Erwan L'Her  1   2   3 , Christelle Teiten  4 , Pierre Bailly  4
Affiliations
Comment

Volatile sedation in critically ills adults undergoing mechanical ventilation: not all inhaled sedatives are equivalent!

Erwan L'Her et al. Crit Care. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Declarations. Competing interests: Pr Erwan L’HER (ELH) is consultant for Sedana Medical and has received grants for an ongoing study about the use of isoflurane within the ICU; he is also consultant for GE Healthcare, co-founder and share-holder of Oxynov Inc. Canada and Ivanae Médical, France outside the current topicDr Christelle Teiten (CT) has no competing interestDr Pierre Bailly (PB) is the main investigator of the Inased study, promoted by CHRU de Brest and granted by Sedana; he has no other competing interest. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable.

Comment on

References

    1. Yamamoto T, Kotani Y, Akutagawa K, Nagayama T, Tomimatsu M, Tonai M, et al. Volatile sedation in critically ill adults undergoing mechanical ventilation: a meta-analysis of randomized controlled trials. Crit Care. 2025;29: 227. - PMC - PubMed
    1. Jabaudon M, Quenot JP, Badie J, Audard J, Jaber S, Rieu B, SESAR Trial Investigators, For the SESAR trial investigators, et al. Inhaled sedation in acute respiratory distress syndrome: the SESAR randomized clinical trial. JAMA. 2025;333:1608–17. - PMC - PubMed
    1. Jabaudon M, Boucher P, Imhoff E, Chabanne R, Faure JS, Roszyk L, et al. Sevoflurane for sedation in acute respiratory distress syndrome. A randomized controlled pilot study. Am J Respir Crit Care Med. 2017;195:792–800. - PubMed
    1. Sneyd JR. Avoiding kidney damage in ICU sedation with sevoflurane: use isoflurane instead. Br J Anaesth. 2022l;129(1):7–10. - PubMed
    1. L’Heudé M, Poignant S, Elaroussi D. Nephrogenic diabetes insipidus associated with prolonged sedation with sevoflurane in the intensive care unit. Br J Anaesth. 2019;122:e73-5. - PubMed

LinkOut - more resources