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. 2025 May 20;6(3):316-319.
doi: 10.1002/jpr3.70035. eCollection 2025 Aug.

Eosinophilic mesenteric vasculitis presenting as inflammatory bowel disease

Razan Alkhouri  1 , Craig Wong  1 , Allyson Richards  1 , David Martin  1 , Joshua Hanson  1 , Rasha Elmaoued  1 , Rajmohan Dharmaraj  1 , Ioannis Kalampokis  2
Affiliations

Eosinophilic mesenteric vasculitis presenting as inflammatory bowel disease

Razan Alkhouri et al. JPGN Rep. .

Abstract

Inflammatory bowel disease (IBD), including Crohn's Disease (CD) and ulcerative colitis, is a chronic inflammatory condition affecting the gastrointestinal tract. Treatment for IBD depends on disease severity and can include medical and surgical management. Advances in treatment and the availability of biologics have significantly reduced the need for surgical interventions. Eosinophilic mesenteric vasculitis (EMV) is a rare form of intestinal vasculitis that can mimic IBD. Diagnosis of EMV is challenging as it requires full-thickness biopsies. It can be mistaken for CD due to its response to steroids, which are a first-line therapy for EMV; however, EMV typically does not respond to other IBD-specific therapies. We present the case of a 15-year-old girl with a history of autoimmune hemolytic anemia who initially appeared to have CD but was diagnosed with EMV following a lack of clinical remission and persistence of the colonic stricture despite biologic therapy, which ultimately led to bowel obstruction symptoms requiring surgical resection.

Keywords: crohn's disease; eosinophilic vasculitis; inflammatory bowel disease.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Computed tomography abdomen and pelvis with IV contrast. Coronal image showing abnormal narrowing at the descending colon as denoted by the arrow.
Figure 2
Figure 2
Computed tomography abdomen and pelvis with IV contrast. Axial image showing the distal ileal stricture as denoted by the arrow.
Figure 3
Figure 3
Arrows showing subintimal hyperplasia of medium‐sized arteries within the submucosa (Hematoxylin and eosin/×4).
See this image and copyright information in PMC

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