Renal Tubular Epithelial Cells as Marker of Tubular Damage in Acute Kidney Disease

Matthijs Oyaert¹, Sigurd Delanghe², Joris Delanghe³, Eric Hoste^{4

5

6}, Marijn Speeckaert^{2

5

6}

Affiliations

¹ Department of Laboratory medicine, Ghent University Hospital, Ghent, Belgium.
² Department of Nephrology, Ghent University Hospital, Ghent, Belgium.
³ Department of Diagnostic Sciences, Ghent University, Ghent, Belgium.
⁴ Department of Intensive Care Medicine, Ghent University Hospital, Ghent, Belgium.
⁵ Research Foundation Flanders, Brussels, Belgium.
⁶ Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent, Belgium.

Matthijs Oyaert et al. Kidney Int Rep. 2025.

. 2025 Jun 9;10(8):2881.

doi: 10.1016/j.ekir.2025.05.052. eCollection 2025 Aug.

Matthijs Oyaert¹, Sigurd Delanghe², Joris Delanghe³, Eric Hoste^{4

5

6}, Marijn Speeckaert^{2

5

6}

¹ Department of Laboratory medicine, Ghent University Hospital, Ghent, Belgium.
² Department of Nephrology, Ghent University Hospital, Ghent, Belgium.
³ Department of Diagnostic Sciences, Ghent University, Ghent, Belgium.
⁴ Department of Intensive Care Medicine, Ghent University Hospital, Ghent, Belgium.
⁵ Research Foundation Flanders, Brussels, Belgium.
⁶ Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent, Belgium.

No abstract available

References

1. Wagner L., Kujat J., Langhans V., et al. Flow-cytometric quantification of urine kidney epithelial cells specifically reflects tubular damage in acute kidney diseases. Kidney Int Rep. 2025;10:1260–1273. doi: 10.1016/j.ekir.2025.01.037. - DOI - PMC - PubMed
1. Kouri T.T., Hofmann W., Falbo R., et al. The EFLM European urinalysis guideline 2023. Clin Chem Lab Med. 2024;62:1653–1786. doi: 10.1515/cclm-2024-0070. - DOI - PubMed
1. Oyaert M., Delanghe J. Progress in automated urinalysis. Ann Lab Med. 2019;39:15–22. doi: 10.3343/alm.2019.39.1.15. - DOI - PMC - PubMed
1. Oyaert M., Delanghe J., Brouwers A., et al. Renal tubular epithelial cells as an easily accessible biomarker for diagnosing AKI post cardiac surgery. Intensive Care Med. 2025;51:870–882. doi: 10.1007/s00134-025-07909-x. - DOI - PubMed
1. Oyaert M., Speeckaert M., Boelens J., Delanghe J.R. Renal tubular epithelial cells add value in the diagnosis of upper urinary tract pathology. Clin Chem Lab Med. 2020;58:597–604. doi: 10.1515/cclm-2019-1068. - DOI - PubMed