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. 2025 Jun 17;10(8):2873-2874.
doi: 10.1016/j.ekir.2025.06.019. eCollection 2025 Aug.

Obinutuzumab in Rituximab-Resistant Podocytopathies: A Single-Center Experience

Affiliations

Obinutuzumab in Rituximab-Resistant Podocytopathies: A Single-Center Experience

Andrea Angeletti et al. Kidney Int Rep. .
No abstract available

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Figures

Figure 1
Figure 1
Response to obinutuzumab in rituximab-resistant podocytopathies. Proteinuria and serum albumin levels before and after obinutuzumab for each patient. In 3 of 6 patients, oral immunosuppressive drug was withdrawn after obinutuzumab: patient 1 stopped calcineurin inhibitor, as patient 3 and 5 who kept mycophenolate mofetil. ProtU, proteinuria; Pt. patient.

References

    1. Noone D.G., Iijima K., Parekh R. Idiopathic nephrotic syndrome in children. Lancet. 2018;392:61–74. doi: 10.1016/S0140-6736(18)30536-1. - DOI - PubMed
    1. Hengel F.E., Dehde S., Lasse M., et al. Autoantibodies targeting nephrin in podocytopathies. N Engl J Med. 2024;391:422–433. doi: 10.1056/NEJMoa2314471. - DOI - PubMed
    1. Trachtman H., Laskowski J., Lee C., et al. Natural antibody and complement activation characterize patients with idiopathic nephrotic syndrome. Am J Physiol Ren Physiol. 2021;321:F505–F516. doi: 10.1152/ajprenal.00041.2021. - DOI - PMC - PubMed
    1. Colucci M., Angeletti A., Zotta F., et al. Age and memory B cells at baseline are associated with risk of relapse and memory B-cell reappearance following anti-CD20 treatment in pediatric frequently relapsing/steroid-dependent nephrotic syndrome. Kidney Int. 2023;104:577–586. doi: 10.1016/j.kint.2023.06.013. - DOI - PubMed
    1. Chan E.Y., Lin K.Y., Yap D.Y., Ma A.L. Obinutuzumab as a viable therapeutic strategy in rituximab-refractory childhood frequently relapsing, steroid-dependent nephrotic syndrome that relapsed during B-cell depletion. Pediatr Nephrol. 2025;40:711–714. doi: 10.1007/s00467-024-06570-8. - DOI - PMC - PubMed

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