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. 1985 Jul-Sep;15(3):247-51.
doi: 10.1007/BF03029195.

Quantitative determination of serotonin released from human platelets

B Marasini, M L Biondi, A Agostoni

Quantitative determination of serotonin released from human platelets

B Marasini et al. Ric Clin Lab. 1985 Jul-Sep.

Abstract

A high-performance liquid chromatographic technique has been used for measuring the amount of endogenous serotonin (5-hydroxytryptamine, 5-HT) released from human platelets stimulated by adenosine diphosphate (ADP) and collagen. Four minutes after challenge both agents induce maximal and similar 5-HT releases corresponding to 14% (ADP) and 17% (collagen) of the intraplatelet 5-HT content. ADP and collagen seem to have different mechanisms of inducing secretion, documented by the different relationship between the release patterns and the optical tracings for aggregation. Endogenous 5-HT release might be useful tool for monitoring states of platelet activation.

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