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. 2025 Aug 15.
doi: 10.1007/s00234-025-03708-9. Online ahead of print.

MRI evaluation of hyperostosis frontalis interna: differentiation and diagnostic insights

Anish Bhandari  1 , Samuel N Rogers  1 , Srinivasan Vedantham  1   2 , Richard Joseph Wruble  3 , Unni Udayasankar  1 , Hasan Ozgur  1 , Raza Mushtaq  4
Affiliations

MRI evaluation of hyperostosis frontalis interna: differentiation and diagnostic insights

Anish Bhandari et al. Neuroradiology. .

Abstract

Introduction: To delineate the MRI characteristics of Hyperostosis Frontalis Interna (HFI) and evaluate its imaging features to aid in accurate diagnosis and differentiation from other pathologies, particularly metastatic disease.

Methods: A retrospective analysis of 74 patients with HFI was conducted. MRI sequences, including pre-contrast T1-weighted, post-contrast T1-weighted, and T2-weighted fat-saturation imaging, were evaluated. Quantitative and qualitative assessments of HFI signal intensity and enhancement patterns were performed. The Hershkovitz classification categorized the extent of HFI.

Results: Pre-contrast T1-weighted imaging showed varied signal intensities, with hypointense regions more common in advanced HFI stages. Hypointense HFI was associated with a lower likelihood (OR: 0.303, CI: 0.113-0.808) and heterogeneous distribution was associated with a higher likelihood (OR: 5.128, CI: 1.982-13.265) of higher Hershkovitz classification (P = 0.0008). Post-contrast T1-weighted imaging revealed that 31% of subjects demonstrated enhancement, with focal geographic enhancement associated with lower CT attenuation values (P = 0.0138), indicating higher fat content. T2-weighted fat-saturation imaging supported the correlation between hypointense signals on pre-contrast T1 imaging and lower T2 signal intensities (P = 0.0022). No significant differences were found in enhancement patterns between different MRI sequences (P > 0.1326).

Conclusions: HFI demonstrates varying appearances on pre- and post-contrast MRI sequences, crucial for differentiating benign HFI from metastatic lesions. Understanding these imaging characteristics can enhance diagnostic accuracy, reduce the risk of misdiagnosis, and improve patient management. Future studies should focus on larger, more diverse populations and explore advanced MRI techniques to further understand HFI.

Keywords: Benign skull Lesions; Calvarial pathologies; Cranial hyperostosis; Hyperostosis Frontalis Interna (HFI); Magnetic Resonance Imaging (MRI).

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Conflict of interest statement

Declarations. Ethics/IRB approval: This research study was conducted retrospectively from data obtained for clinical purposes. We consulted extensively with the institutional review board of the University of Arizona, who reviewed and approved our protocol under study #00000962 on March 30, 2022. An institutional review board official waiver of ethical approval was granted from the institutional review board of our institution. Conflict of interest: We declare that we have no conflict of interest.

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