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. 2025 Aug;17(8):e70146.
doi: 10.1111/1753-0407.70146.

Sleep Phenotypes, Genetic Susceptibility, and Risk of Obesity in Patients With Type 2 Diabetes: A National Prospective Cohort Study: A Commentary

Nimra Khan  1 , Rida-E-Zehra  1 , Nandni Dileep  1
Affiliations

Sleep Phenotypes, Genetic Susceptibility, and Risk of Obesity in Patients With Type 2 Diabetes: A National Prospective Cohort Study: A Commentary

Nimra Khan et al. J Diabetes. 2025 Aug.

Abstract

This commentary discusses the study "Sleep Phenotypes, Genetic Susceptibility, and Risk of Obesity in Patients with Type 2 Diabetes: A National Prospective Cohort Study" by Xi et al. The study provides a perceptive investigation of how metabolic characteristics and genetic variables interact to affect body mass index (BMI) in people with T2D. It has some limitations, including reliance on self-reported sleep data and lack of in-depth sleep quality assessment. We highlight the importance of objective sleep data, detailed assessments of sleep quality, and advanced polygenic risk models in future research to better understand these relationships and inform precision diabetes care.

Keywords: genetic susceptibility; obesity; sleep phenotypes; type 2 diabetes.

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Conflict of interest statement

The authors have nothing to report.

The authors declare no conflicts of interest.

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