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. 1977 Aug 15;33(8):1076-7.
doi: 10.1007/BF01945979.

A tissue-selective prostaglandin E2 analog with potent antifertility effects

H J Hess, J S Bindra, J W Constantine, W Elger, O Loge, E Schillinger, W Losert

A tissue-selective prostaglandin E2 analog with potent antifertility effects

H J Hess et al. Experientia. .

Abstract

N-methanesulfonyl 16-phenoxy-omega-tetranor PGE2 is a prostaglandin analog which is markedly more tissue selective than PGE2. This compound is 10-30 times more potent than PGE2 in animal models which are considered relevant to antifertility effects in humans. In pharmacological tests which are believed to be predictive for side effects in humans, the compound has potency either equal to or less than that of PGE2.

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