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Review
. 2025 Aug 16.
doi: 10.1007/s12094-025-04007-8. Online ahead of print.

Single-cell sequencing: accurate disease detection

XiaoQin Wang  1 , NianNian Li  1 , Wei Wang  2 , Bing Liu  3
Affiliations
Review

Single-cell sequencing: accurate disease detection

XiaoQin Wang et al. Clin Transl Oncol. .

Abstract

Early and accurate detection of diseases is of great significance for enhancing treatment outcomes and improving patient prognosis. The emergence of single-cell sequencing technology has brought new opportunities for this. This technology breaks through the limitations of traditional sequencing and can analyze the genome, transcriptome, etc. at the single-cell level, clearly demonstrating the heterogeneity between cells. In neurological diseases, single-cell sequencing can reveal the changes in gene expression of nerve cells in the early stage of the disease, facilitating early diagnosis and disease monitoring. Although single-cell sequencing has broad prospects in disease detection, it faces challenges such as complex data processing and high detection costs. With the continuous advancement of technology, single-cell sequencing is expected to become a key means for accurate disease detection, bringing about a revolution in clinical diagnosis.

Keywords: Accurate disease detection; Single-cell sequencing; Tumor.

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Conflict of interest statement

Declaration. Conflict of interest: The authors declare no conflict.

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