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. 2025 Jul 15;17(7):5465-5474.
doi: 10.62347/VKEY9889. eCollection 2025.

Off pump method of coronary artery bypass grafting enhances therapeutic efficacy and safety in elderly coronary heart disease patients

Jin-Dong Li  1 , Zhen-Kun Li  1 , Xu Liu  1 , Jian-Tang Wang  1 , Shou-Dong Cai  1 , Sheng-Jun Ma  1
Affiliations

Off pump method of coronary artery bypass grafting enhances therapeutic efficacy and safety in elderly coronary heart disease patients

Jin-Dong Li et al. Am J Transl Res. .

Abstract

Objective: To compare the therapeutic effects of off-pump versus conventional coronary artery bypass grafting (CABG) in elderly coronary heart disease (CHD) patients.

Methods: This retrospective study analyzed 98 elderly CHD patients (47 conventional CABG, 51 off-pump CABG) treated between April 2019 and March 2021. Outcomes included intraoperative and postoperative indicators (distal anastomoses, mechanical ventilation time, hospital stay), graft patency, left ventricular function (LVEF, LVEDD), cardiac biomarkers (cTnI, CK, CK-MB), complication rates, 3-month quality of life (QoL), and long-term major adverse cardiovascular and cerebrovascular events (MACCE).

Results: The two groups had similar distal anastomoses and graft patency rates (P>0.05). However, the off-pump group had shorter mechanical ventilation time and hospital stay than the conventional group (both P<0.05). LVEF and LVEDD showed no significant differences between the two group pre- and post-surgery. Cardiac biomarkers (cTnI, CK, CK-MB) increased postoperatively in both groups but were significantly lower in the off-pump group (P<0.05). The off-pump group had fewer complications, better QoL scores in social, mental, emotional, and overall health, and lower long-term MACCE incidence than the conventional group (all P<0.05).

Conclusion: Off-pump CABG reduces surgical trauma, shortens recovery time, lowers complication rates, and improves QoL compared to conventional CABG, making it a preferable option for elderly CHD patients.

Keywords: CABG; Off-pump; cardiac function; cardiopulmonary bypass; elderly coronary heart disease.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Flow chart of study design. OPCABG: off-pump coronary artery bypass grafting; CCABG: conventional coronary artery bypass grafting; LVEF: Left Ventricular Ejection Fraction; LVEDD: Left Ventricular End-Diastolic Diameter; cTn I: cardiac troponin I; CK: Creatine Kinase; CK-MB: Creatine Kinase-Myocardial Band.
Figure 2
Figure 2
Comparison of cardiac function before and 3 months after surgery in the two groups. A: Comparison of LVEF before and after treatment in the two groups; B: LVEDD in the two groups before and after treatment. OPCABG: off-pump coronary artery bypass grafting; CCABG: conventional coronary artery bypass grafting; LVEF: Left Ventricular Ejection Fraction; LVEDD: Left Ventricular End-Diastolic Diameter.
Figure 3
Figure 3
Comparison of cardiac function-related indicators before and 3 days after surgery. A: Comparison of cTnI before and after treatment in the two groups of patients; B: Comparison of CK before and after treatment in the two groups of patients; C: Comparison of CK-MB between the two groups of patients before and after treatment. * indicates P<0.05. OPCABG: off-pump coronary artery bypass grafting; CCABG: conventional coronary artery bypass grafting; cTn I: cardiac troponin I; CK: Creatine Kinase; CK-MB: Creatine Kinase-Myocardial Band.
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